The article is devoted to study biological effects of cerebrospinal fluid of lactate cows with its injection into female and male white rats as a xenogenic medicine. We studied the reproductive systems by physiological and morphological methods. We pointed significant, but reversible inhibitory effect of cerebrospinal fluid derived during physiological anovulation of a donor, we analyzed this effect of the recipient’s reproductive system. Inhibitory effect of cerebrospinal fluid on gonad was identified both in male and female organisms. This effect is reversible and dependable on recipient’s age and cerebrospinal fluid frequency of administration. Thus, the peak changes were observed during cerebrospinal fluid injection in perinatal period and numerous injections. There were the following changes: mating number and sexual motivation reducing; dynamic of estrous cycle and phases of cycle duration; female’s fertility decrease and temporary male infertility; testicles and ovary weight reductions, reproductive hormones level in blood serum, anovulation was caused by artresia of tertiary follicles and structural changes of target-organs for ovarian hormones. The article has validated the hypothesis about absence of cerebrospinal fluid immunogenetic disparity of different mammal species and hypothesis about its contraceptive effect on derived samples during the donor’s physiological anovulation. We preserved normal characteristics of cerebrospinal fluid by intravital derivation, cryoconservation and we did not do filtration. Thus, we studied injected fluid as biological media and the biogenic medicine.

The aim of the article is devoted to study microcirculation flow disorder and peripheral hemodynamics in children, who have responsive arthropathia. There were given data concerning peculiarities and correlations between microcirculation and peripheral hemodynamics under responsive arthropathia in children. Microcirculation functional changes were pointed out. These changes dealt with influence on both flow distribution components and exchanging, draining components. It was pointed that hemodynamics disorders in proximal area of the hurt joint had compensatory character, while the distal area obtained decompensatory character. There was direct correlation among responsive arthropathia disease severity, ill person age, microcirculation flow disorder level and peripheral hemodynamics. Thus, disease severity worsening and age increasing leaded to severity of microcirculation and hemodynamics disorders.

The article deals with the liver structural changes of experimental rodents of juvenile age, who were under 10- or 30-times hypergravitation influence. These changes mostly have reversible character and are accompanied by adaptive-compensative mechanism activization. They are directed to reduce negative influence of exogenic factors. Both structural-functional changes and adaptive reaction intensivety dominate in the rodent subgroup, which got more influence. Obtained gysto- and cytomorphological data prove positive adaptive response establishment on cellular level. First of all this positive adaptive response is characterized by cell quantity increasing of different mitosis stages. Most obvious histopathological changes were found in the mature rodent subgroup, which are characterized by cytomorphological traits of the vacuolar degeneration and non-adequate adaptive response realization. However, more obvious negative influence of the overload was pointed in the longer term experiment (30-times hypergravitation influence).

Epidemic of HIV-infection began in Sumy region in 1996. Rapid growth of morbidity appeared in the early ХХI century, so it increased up to 18.5 cases per 100 thousand population in 2010. Nowadays certain stabilization is pointed like, 14.7 cases per 100 thousand population with the growth rate -12.7% in 2012. The widest HIV-infection prevalence is observed in Shostka, Romesky and Krolovetsky districts. This is cased by the high traffic network of these districts and closeness to deprived territories of the other regions. If majority of the infected was male in the epidemic beginning, so nowadays number of the new infected by gender is roughly equal. The number of children and persons of ripe years have dramatically increased (up to 27% and 31% respectively). During ten years HIV-infection transferred from infected drug addicts to general human population and these have cardinally turned the viral transmission of sexual and parenteral routes (51.8% and 18.2% respectively in 2012). The problem may occur because of the unregistered HIV-carriers accumulation.

The article studied age-related peculiarities of morphological cerebral sinus vascular plexus structure of the white rats in their presenile age. There was analyzed dependence on xenogenic spinal fluid frequencies of administration with the following characteristics: animal weight, brain weight, length and width of hemispheres, cephalization coefficient, height and width of choroid ependymocytes. It was pointed that in years typical involutional changes of vascular plexus took place, while exogenic administration of xenogenic spinal fluid had positive influence on the brain biometric data and vascular plexus of cerebral sinus microscopic parameters.

The article presents the current understanding of the cytokine system and genes that encode them, defined the role of single nucleotide polymorphisms in the character of the course of viral hepatitis, the adverse effects of the disease, the effectiveness of antiviral treatment and severity of adverse effects during therapy.

The scope of the article was to study expression of adhesion molecules and screen respiratory functions in the patients with diabetic nephropathy of different chronic renal disease progression. Interaction between on the one hand: E-Selectine molecule levels, sICAM, sVCAM and MAU, proteinuria of first-state chronic renal disease, and on the other hand respiratory functions and creatinine of third-state chronic renal disease. Obtained data will be useful for early prognosis of renal irritation and pulmonary affection signs of diabetes mellitus.

Article is about anatomists, who were papal physicians: M.R. Colombo (c.1515-1559), G.B. Canano (1515-1579), G.C. Aranzi (1530-1589), C. Varolio (1543-1575), A. Cesalpino (1525-1603), M. Malpighi (1628-1694), G.M. Lancisi (1654-1720) and G. Flaiani (1739-1808). Their contribution into anatomy and brief biographical information are given.

The scope of this article was to recommend treatment and prevention measures against pyoinflammatory infections in the newborns and parturient women. The aim is based on spread of infection peculiarities analysis and antibiotic susceptibility of microorganisms gathered in the inpatient maternity facilities. We used bacteriological, epidemiological and statistical research methods. We identified an annual number increase of contaminated samples by microorganisms as well as certain species changed etiological profile. Existence of colonization by opportunistic pathogenic microorganisms of different biotopes was pointed out in every second pregnant woman. Thus, it led to the risk of fetus or newborn contamination possibility. During the research we figured that the majority of derived microorganisms were multiresistant to antibiotics. The most effective antibiotics against E. coli were laevomycetin and meropenem, against P. Aeruginosa – cefatidime. The majority of gram-positive coсci showed antibiotic sensitivity to amikacin and cefazolin. Antibiotic susceptibility analyze pointed on two ecovariants of P. aeruginosa formation in the Regional Perinatal Center. Derived data can be a key for the development of antibacterial therapy principles and antibiotic rotation in the medical institutions.

Cleft hand is a congenital deformity of the hand consisting of varying absence of the central structures of the hand. One form is the V-shaped cleft in the palm with severe narrowing of the web space and absence of the middle finger. Most peer-reviewed studies in the scientific literature describe surgical treatment during childhood. This study illustrates our experience with treating cleft hand deformity in a skeletally mature patient. We describe a novel surgical technique and the 3 year results using a Z-shaped carpal bone osteotomy reconstruction in a 22 year-old woman results.

The content of main pro- and anti-inflammatory cytokines in serum of the patients with traumatic brain injury immediately after surgical operation and 10 days later was studied in the article. Concentrations of IL-1β, IL-2, IL-6 increased significantly without elevation of IL-4 and γ-IFN. Ratio IL-1β/IL-4 increased too. After 10 days of usual therapy we observed absence of their dynamics. It was a basis for the immunocorection.

The aim of our study was to investigate the apoptotic activity and necrosis of neutrophils of peripheral blood as objectification indicators of clinical course of community-acquired pneumonia in infants. There were examined 73 infants with community-acquired pneumonia. In infants with community-acquired pneumonia intensity of apoptosis increases, with the increase of disease severity apoptotic activity - decreases. Necrotic processes exhibit a positive relationship with the severity of this disease, which may serve for effective objectification of clinical course of community-acquired pneumonia in infants and to predict the severity of the disease in this category of patients.

The article presents literature data based on the pleiotropic effects of non-steroidal anti-inflammatory drugs and demonstrated the results of their research on assessment of diclofenac, nimesulide and meloxicam on lipid metabolism, coagulation characteristics of blood, level of uric acid, liver function tests in patients with osteoarthritis, taking into account the presence of cardiovascular risk. It is shown that the most appropriate medication that could serve as a drug of choice in treating a specified group of patients is diclofenac-retard that has sufficient clinical effect and minor hypolipidemic and hypocoagulation action.

Uncomplicated fractures of the thoracolumbar region are widespread pathology. These kinds of spine injuries represent over half all spine fractures. There are modern classifications of spine injuries and their biomechanical structure. The three column classification of Denis was developed to show the injury mechanism and its further treatment. Patients mostly complain of severe local back pain and radiculopathy. Results of puncture percutaneous vertebroplasty (PPVP) method in surgery were given. Under the experiment were 55 patients in their 51+1.2 years suffered traumatic compressive fractures of vertebral bodies. We have operated 55 patients. Pain syndrome strength was evaluated with Visual Analogue Scale. Such positive postoperative dynamics as pain syndrome regress and patient’s quality of live improvement were noticed. Thus, PPVP is considered to be minimally invasive and extremely effective method to treat traumatic compressive vertebral body fractures.

We analyzed 10 samples of histological material (mammary gland tissue) from 6 women with precancerous breast pathology. The levels of estrogen, progesterone, mammaglobin receptor’s expression were defined. The same histological structure appeared nonhomogeneous according to immunogistochemical test-results. This may respresent the characteristics of the hormonal status and the age of patients, and also be a manifestation of breast cancer and an indicator of a predisposition to it.

The article is based on decadelong monitoring of 123 general-family practice institutions located in the rural area. It was pointed that medical care quality improving caused by: diagnostic equipment completeness, certain day patient facilities number and capacity enlarging, geographically-territorial accessibility reforming, normalization of population general number regarding to the certain institution. Obtained data dealt with significant changes caused by geographically-territorial accessibility, ambulatory completeness of a general practitioner and the new qualimetry approach usage. Thus, the approach can be involved into similar analyzes, Health Care System quality monitoring and managerial decision evaluation of effectiveness.

Investigated the prevalence of hypovitaminosis D among 135 patients with coronary heart disease (CHD), stable angina pectoris class II-III, who were divided into two groups depending on the presence of metabolic syndrome (MS). The degree of vitamin D deficiency determined by the concentration of 25(OH) D in the blood. 91.9% of participants has deficiency and insufficiency of vitamin D. Patients with CHD associated with MS are significantly more pronounced hypovitaminosis D (p<0.001), the average concentration of 25 (OH) D was 43.8 ± 1.82 nmol/l. Concentration of vitamin D was significantly higher in the summer and autumn months compared to winter. Patients in age 60-70 and older than 70 years has significantly lower concentration 25(OH)D (p<0.001) compared to patients of 40-50 years.

The problem of hypoxia for many years is very relevant and attracts the attention of physiologists and clinicians in terms of the mechanisms of various pathological conditions. Effects of antenatal hypoxia in the infants depend on the severity of exposure, individual tolerance and the age of fetus. In the literature, there is a large amount of data on the effect of antenatal hypoxia during last trimester of pregnancy on the development of the newborn. There is a reduction of oxygen supply to the parts of the body below required for adequate perfusion. At present researchers think about application of a number of regulatory peptides and their constellation to correct the consequences of shock states, including antenatal hypoxia. Cardioprotective effect is achieved due to sufficient energy supply, which helps to maintain normal cardiac contractility. Research and application of new antioxidant drugs in cardiology practice that can enhance the effectiveness of treatment of patients with myocardial infarction are highly relevant.