Introduction. Antimicrobial resistance (AMR) is a major problem with a negative impact on animal health and public health worldwide. Actions to reduce this phenomen are of major importance and require collective management in the context of "one health". Material and methods. The research material constituted the legislative acts that regulate the activity of the veterinary sanitary service within the National Agency for Food Safety, statistical data regarding the use of antimicrobial in the animal population from the republic. Results. The analysis of the data presented in the paper is focused on the legal acts of activity of the veterinary service in order to reduce the effect of RAM at the national level with the involvement of the authorities in the field of human and animal health, as well as environmental protection. Conclusions. The reduction of AMR at the national level can be achieved by creating an institutional framework responsible for intersectoral coordination and collaboration as well as the effective implementation of control of the release of animal medicaments only on the basis of veterinary prescriptions.

Introduction. Antimicrobial resistance (AMR) is a major problem with a negative impact on animal health and public health worldwide. Actions to reduce this phenomen are of major importance and require collective management in the context of "one health". Material and methods. The research material constituted the legislative acts that regulate the activity of the veterinary sanitary service within the National Agency for Food Safety, statistical data regarding the use of antimicrobial in the animal population from the republic. Results. The analysis of the data presented in the paper is focused on the legal acts of activity of the veterinary service in order to reduce the effect of RAM at the national level with the involvement of the authorities in the field of human and animal health, as well as environmental protection. Conclusions. The reduction of AMR at the national level can be achieved by creating an institutional framework responsible for intersectoral coordination and collaboration as well as the effective implementation of control of the release of animal medicaments only on the basis of veterinary prescriptions.

Introduction. Antimicrobial resistance (AMR) is a major problem with a negative impact on animal health and public health worldwide. Actions to reduce this phenomen are of major importance and require collective management in the context of "one health". Material and methods. The research material constituted the legislative acts that regulate the activity of the veterinary sanitary service within the National Agency for Food Safety, statistical data regarding the use of antimicrobial in the animal population from the republic. Results. The analysis of the data presented in the paper is focused on the legal acts of activity of the veterinary service in order to reduce the effect of RAM at the national level with the involvement of the authorities in the field of human and animal health, as well as environmental protection. Conclusions. The reduction of AMR at the national level can be achieved by creating an institutional framework responsible for intersectoral coordination and collaboration as well as the effective implementation of control of the release of animal medicaments only on the basis of veterinary prescriptions.

Introduction. Antimicrobial resistance (AMR) is a major problem with a negative impact on animal health and public health worldwide. Actions to reduce this phenomen are of major importance and require collective management in the context of "one health". Material and methods. The research material constituted the legislative acts that regulate the activity of the veterinary sanitary service within the National Agency for Food Safety, statistical data regarding the use of antimicrobial in the animal population from the republic. Results. The analysis of the data presented in the paper is focused on the legal acts of activity of the veterinary service in order to reduce the effect of RAM at the national level with the involvement of the authorities in the field of human and animal health, as well as environmental protection. Conclusions. The reduction of AMR at the national level can be achieved by creating an institutional framework responsible for intersectoral coordination and collaboration as well as the effective implementation of control of the release of animal medicaments only on the basis of veterinary prescriptions.

Introduction. With syntropy of CVD and AH, the pathology of the digestive system can exacerbate the course of AH and develop special conditions for increasing the risk of cardiovascular complications. Pharmacotherapy of HD may affect the course and progression of gastroesophageal reflux disease. Material and methods. The study was conducted using the PubMed, Z-library, NCIB, Medscape, Mendeley databases using the keywords: “syntropy”, “comorbidity”, “arterial hypertension”, “acid-dependent diseases”, “gastric ulcer”, “gastroesophageal reflux disease”. Results. AH and CVD are quite often observed together, having, moreover, a conditioned commonality of the mechanisms of formation. The proximity of the location with the heart, the commonality of innervation, in the pathology of the esophagus, can create viscero-visceral reflexes and provoke arrhythmias, imitate coronary heart disease. Pathology of the upper gastrointestinal tract can lead to functional disorders of the cardiovascular system, manifested through the autonomic nervous system. The combined course of AH and CVD, observed, according to various sources, from 11.6% to 50%, is not just random, but may have pathogenetic and etiological patterns. Comorbidity of CVD and AH can enhance the development of the main pathological process and lead to disruption of adaptive mechanisms. Conclusions. The syntropy of AH and CVD requires thorough scientific studies to discover and elucidate the pathogenetic features of the course and methods of better drug therapy.

Introducere. Pastrarea durabila si eficienta a microorganismelor în colec?ii depinde de selectarea corecta a metodei de conservare, parametrilor si mediilor de protectie. Material ?i metode. A fost evaluata viabilitatea ?i stabilitatea particularita?ilor morfo-culturale a drojdiilor din CNMN, pastrate sub un strat de ulei de vazelina ?i în stare liofilizata timp de 15 ani. Rezultate. Studiul viabilita?ii a 17 tulpini de drojdii din CNMN, dupa 15 ani de depozitare prin metodele: liofilizare ?i sub un strat de ulei de vazelina, a demonstrat ca, viabilitatea ?i stabilitatea acestora variaza în dependen?a de gen. Astfel, viabilitatea tulpinilor liofilizate, din genul Rhodotorula a variat în limitele 47,0-65,7%, din genul Saccharomyces – 46,4-58,8%, iar din genul Lipomyces – 64,0-77,8%, comparativ cu viabilitatea înregistrata dupa liofilizare. De asemenea, s-a stabilit ca toate tulpinile de drojdii, pastrate sub uleit de vazelina, sunt viabile, dar prezinta unele modificari ale particularita?ilor morfo-culturale. Astfel, la tulpinile din genul Rhodotorula ?i genul Saccharomyces, inoculate pe medii agarizate, coloniile în primul pasaj erau foarte mici, culoarea diferita de cea ini?iala. La tulpinile din genul Lipomyces astfel de modificari nu au fost depistate. S-a demonstrat ca, particularita?ile morfo-culturale ini?iale se restabilesc mai repede, daca culturile, pastrate sub ulei, sunt inoculate în mal? lichid, apoi efectuate 2-3 pasaje consecutive pe medii agarizate. Concluzii. Metodele de conservare a tulpinilor de drojdii în stare liofilizata sau sub un strat de ulei de vazelina, sunt foarte eficiente ?i de perspectiva, asigurând o viabilitate ?i stabilitate înalta.

Introduction. The fight against tuberculosis (TB) as an infectious and socially significant disease and the protection of childrens health, representing one of the urgent problems of the 21st century, retain priority positions in national medicine. Material and methods. Analysis of reporting statistical data on tuberculosis in children for 2016-2021 and the main sections of TB practice. Results. Epidemiological indicators are presented that characterize the burden of TB incidence cases (new cases and recurrences) in children, its dynamics, as well as the structure of clinical forms, features of modern diagnostics and the evolution of the tuberculosis process in patients of diverse ages. The influence of anti-epidemic measures conditioned by the COVID-19 pandemic was noted. The increasing importance of Mycobacterium tuberculosis drug resistance in the choice of chemotherapy regimen is shown. A quantitative and qualitative assessment of specific prevention, predictors and determinants of TB is given. Conclusion. The results indicate that the key direction for the prevention and control of TB in the Republic of Moldova should remain the integration and consolidation of efforts in providing anti-TB care to the pediatric population and adolescents.

Introduction. COVID-19 infection is common in the pediatric population, presenting a variety of respiratory manifestations and complications. Material and methods. The study included 64 children from the COVID-19 section, IMSP IMC, with a mean age of 2,04±0,4 years (variations 1 day-17 years), divided into 5 age groups: 0-1 month, 1-12 months, 1-3 years, 3-7 years, >7 years. The methodology of the study is expected to assess the significance of clinical manifestations in the COVID-19 infection episode. Results. With 21 cases, this study discovered a higher frequency of the disease in infants. The nosological expression of the infection was dominated by pneumonia and unique cases of infection in four children with upper respiratory infections. Every evolution was presented by 11 children, the moderate form being the dominant one. An almost constant sign in the children in the study was a febrile syndrome, which in 31 cases was > 38,0oC. Every second child showed catarrhal respiratory signs, cough, and cyanosis in 66,1% of the children, chest circulation in 32,1% of the cases, wheezing in 6. COVID-19 infection in hospitalized children resulted in respiratory complications in 81,3% of cases and toxic infections – 23,4%. Conclusions. COVID-19 infection in hospitalized children occurs mainly with pneumonia and only in unique cases of nasopharyngitis, with the constant presence of catarrhal respiratory signs, dyspnea, and fever, but also a susceptibility to develop severe forms and complications.