Articles of Volume : 2 Issue : 5, September, 2018 |
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A 100 year review of the evolution in neurosurgical thinking regarding compound depressed skull fractures |
Author : Adrian Kelly |
Abstract | Full Text |
Abstract :This review was conducted by performing a PubMed search of the English literature with search words “skull fracture; compound skull fracture; compound depressed skull fracture; skull fracture assault” and synonyms thereof. |
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Oxidative Damage in Neurodegenerative Diseases: Relevance of Dietary Antioxidants |
Author : Michael Sherman |
Abstract | Full Text |
Abstract :Oxidative stress is induced by an imbalanced redox states, involving either excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system. The brain is one of organs especially vulnerable to the effects of ROS because of its high oxygen demand and its abundance of peroxidation-susceptible lipid cells. Previous studies have demonstrated that oxidative stress plays a central role in a common pathophysiology of neurodegenerative diseases such as Alzheimers disease and Parkinsons disease. Antioxidant therapy has been suggested for the prevention and treatment of neurodegenerative diseases, although the results with regard to their efficacy of treating neurodegenerative disease have been inconsistent. |
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Advances in the prevention of Alzheimers disease: A Review on Role of Amyloid-ß pathology |
Author : Parlovich Fletcher |
Abstract | Full Text |
Abstract :Definitions and diagnostic criteria for all medical conditions are regularly subjected to reviews and revisions as knowledge advances. In the field of Alzheimers diagnostic nomenclature to undergo major re-examination. The shift towards presymptomatic and pre-dementia stages of AD has brought prevention and treatment trials much closer to each other than before. Here we discuss: (i) the impact of diagnostic reliability on the possibilities for developing preventive strategies for AD; (ii) the scientific evidence to support moving from observation to action; (iii) ongoing intervention studies; and (iv) the methodological issues and prospects for balancing strategies for high-risk individuals with those for broad population-based prevention. The associations between neuropathology and cognition are still not entirely clear. In addition, the risk factors for AD dementia and the neuropathological hallmarks of AD may not necessarily be the same. Cognitive impairment has a clearer clinical significance and should therefore remain the main focus of prevention.
Amyloid-ß peptide (Aß) seems to have a central role in the neuropathology of Alzheimers disease (AD). Familial forms of the disease have been linked to mutations in the amyloid precursor protein (APP) and the presenilin genes. Disease-linked mutations in these genes result in increased production of the 42-amino-acid form of the peptide (Aß42), which is the predominant form found in the amyloid plaques of Alzheimers disease. |
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