Symptomatic trigeminal neuralgia sometimes occurs secondary to intracranial skull base tumor. GKRS has been reported as a potential treatment option for tumor-related trigeminal neuralgia. However, there is paucity of literature from India on the clinical outcome of GKRS for symptomatic trigeminal neuralgia.

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a disabling condition requiring immunosuppressive or immunomodulatory drug treatment. However, approximately 20% of patients do not respond to classical immunosuppressive drugs. Rituximab (RTX) is beneficial for patients with refractory CIDP.

Posterior reversible encephalopathy syndrome (PRES) is a rare underestimated neurological condition characterized by non- specific symptoms like headache, seizure, altered mental status, visual disturbance, and a typical finding of edema in the posterior white matter of the brain, without any signs of infarction.

Neuritin, also known as CPG-15 is a protein that plays a crucial role in neural development and synaptic plasticity. Apart from this neurological function, Neuritin has been recognised for its potential role in various immunological functions. Re- cent researches have proven that regulatory T cells, (a subset of T lymphocytes) involved in immune regulation, are associated with Neuritin production and could potentially modulate numerous immune responses. Based on few clinical studies, the production of Neuritin in the body with the help of foxP3 signaling pathway could act as a potential weapon against anaphylactic (IgG) and atopy (IgE) related Hypersensitivity reactions.

The authors of this publication describe herein a cluster of symptoms and behaviors in patients with ADHD. The authors have called this Rejection Sensitivity Dysphoria (RSD), as episodes begin with the experience of perceived rejection, demonstrating rejection sensitivity, that progresses into a nearly instantaneous dysphoric mood, which causes significant distress and impairment. We present a case series of four case studies from the first author’s private practice in great detail. At present, the authors have seen hundreds of patients and clients with this same clinical profile (ADHD with RSD), which the authors have not been able to attribute to any other known comorbid psychopathology with ADHD (i.e., mood disorders, anxiety disorders, personality disorders, or other developmental disorders). Notably, clinicians worldwide have contacted the first author, confirming that they have seen ADHD patients and clients who have presented with this in their professional experience.

Subacute sclerosing panencephalitis is a primary progressive chronic neurological disorder associated with demyelination that affects one in a million people in the West, but despite the availability of a widespread measles vaccination, it affects 21 people per million in developing nations like India [1,2]. Measles is primarily an infection that affects children between the ages of one and two. In contrast, SSPE is a long-term side effect that develops from a primary measles infection in a specific group of children and usually manifests six to eight years after the initial infection. This is the mutant measles virus’s latent phase, during which it multiplies in neural cells by eluding humoral protection. The development of SSPE is indicative of a malfunctioning cell- mediated immune response during the initial measles infection, which leads to the development of an early humoral immunity and promotes intraneuronal infection

Trigeminal neuralgia with the vertebrobasilar artery as the responsible vessel is relatively rare. Trigeminal neuralgia involving the vertebrobasilar artery is a difficult surgical procedure with a high complication rate. In this report, we describe our recent surgical experience of successfully managing trigeminal neuralgia involving the vertebrobasilar artery.

Horizontal gaze palsy with progressive scoliosis (HGPPS) is an uncommon congenital cranial dysinnervation disorder that affects both eye movement and spinal curvature, marked by limited ability to move eyes in horizontal gaze, worsening curvature of spine and brainstem malformations [1]. Only a few cases have been reported from India [2,3]. It is mainly described in consanguineous families. It is linked to a specific gene mutation in the ROBO3 gene located on the 11q23-q25 region of chromosome 11 [4]. It has characteristic clinical and radiological features. Here we present a case of an adolescent male patient with characteristic features of HGPPS.