Plerixafor is a CXCR4 receptor inhibitor, which was recently introduced for stem cell mobilization in myeloma and lymphoma patients prior to their transplantation. Since March 2009, we performed 16 mobilizations using plerixafor in combination with G-CSF in 10 patients with multiple myeloma, 3 Non-Hodgkin’s lymphoma and 3 Hodgkin’s lymphoma, who failed previous mobilization attempts with G-CSF in combination with chemotherapy.

There is a common opinion that Indians have more tendencies to develop greater waist circumference and waist to hip ratio, thus having a greater degree of central obesity. This total abdominal and visceral fat increases insulin resistance and the development of type 2 diabetes with elevated blood pressure.

Communicable diseases (including HIV/AIDS, malaria, tuberculosis, schistosomiasis, river blindness, Chagas,sleeping sickness, and leishmaniasis) disproportionately affect the people living in resource-limited countries.While current patent system does not work for poor end users in these countries, it adds to the stranglehold on accessto lifesaving medicines by the protectionist policies of wealthy countries. Nonetheless, increasing pressure is registerednowadays for strategies up to promoting pharmaceutical innovation, research and development (R AND D) and equitableaccess to medicines in the sake of the worst-off. Method: Analysis here will compare some strategy models in theirpotential to fairly attune patents to innovation, R AND D and access, in the light of new perspectives by governments andinstitutions aligning with the spirit and resolutions of just closed sixty-third WHO World Health Assembly. Conclusion:No single model is likely to be enough solution, and a combination of two or more may be needed to ensure thatoutputs of R AND D, innovation and access are available without restrictions. To this aim, all models should complementcurrent intellectual property regimens and channel open source schemes, sustainable financing mechanisms, andneeds-driven rather than merely market-driven rules.

The development of head and neck cancers is associated with extensive use of tobacco and/or tobacco like products and alcohol; excessive consumption of processed meat and fish; exposure to certain occupational hazards; and infection with certain oncogenic viruses. At least some of these risk factors are operative in the Republic of Suriname. This suggests that the population may run a greater than average risk for head and neck cancers. In this study, the incidence of this group of cancers in Suriname has been determined for 1980 through 2004. The data obtained have been stratified according to anatomical location, gender, age, as well as ethnic background, and compared with global values.

We retrospectively reviewed 21 National Australian University academic websites for swine flu guidelines for pregnancy and therapeutic measures. This study was conducted at the height of the swine flu epidemic in Australia, August 2009. No detailed information on the use and safety of neuraminidase-inhibitors, across population sub-groups were identified within the content pages of Australian University Websites. Further concern was an absence of information on which antiviral and vaccination treatments are appropriate for pregnant women and breastfeeding mothers. Pregnant women are at high risk of developing severe illness and related complications with the onset of swine flu. It is thus important that pregnant women have access to adequate web site information and updated information advising on appropriate use of anti-viral neuraminidase-inhibiting drugs and treatment, vaccination and options for associated fever and information that they represent a high risk subgroup.

Inconclusive protocol and consensus exist at present time regarding treatment of patients who have developed Osteonecrosis of the Jaw (ONJ) following administration of intravenous Bisphosphonates. Most clinicians are avoiding treatment for patients presenting with BRONJ due to lack of predictable treatment outcome.Findings: In this case report, patient was suffering from a non healing lesion on anterior mandible, which was not responsive to any conventional treatment. Patient was recommended to rinse with the PBSCD for treatment of BRONJ (Bisphosphonate Related Osteonecrosis of the Jaw) lesion seen on some patients who were on intravenous Bisphosphonate medications for multiple myeloma. Patient was recommended to rinse three times a day with PBSCD. After 4 month use of the solution patient presented with soft tissue healing on previously exposed necrotic bone on mandibular anterior region.Conclusion: The benefit of Phosphate buffer-stabilized 0.1% chlorine dioxide-containing mouth wash (PBSCD) is discussed. This is a non invasive protocol that has proved to be effective in closing of an open wound

If I have to name the most momentous concept for biomedicine in the last decade, I would certainly go for the term “translational” without any hesitation. Not only it describes the vast array of biomedical research activities that relate to the study of human disease, their treatment and prevention; it also directs the processes of novel drug discovery and medical devices invention that directly or indirectly affects our economy as a whole.