Objective: This study aimed to examine the effect of physical activity at varying intensities on anxiety, blood pressure, and blood glucose levels in primiparous women aged 20-30 years.

It is well established that knowledge is the key factor in optimal diabetes control.

Objective: This study aimed to investigate the impact of rumination and alexithymia on the general self-efficacy of individuals with diabetes.

Objective: Obesity involves complex pathological mechanisms. Multi-herbal formulations targeting diverse pathways may provide synergistic therapeutic benefits. This study aimed to evaluate the anti-obesity effects of a standardized multi-herbal formulation (GUTAC), consisting of Glycyrrhiza glabra, Urtica dioica, Trigonella foenum-graecum, Artemisia persica and Camellia sinensis. Materials and Methods: Obesity was induced in male Wistar rats (n= 30) via a high-fat diet (HFD) for three months. Subsequently, the rats were divided into three groups (n= 10 per group): (1) HFD alone, (2) HFD with GUTAC, and (3) standard diet (SD) with GUTAC, for an additional three months. Key parameters such as body mass index (BMI), blood biomarkers, and histopathological changes in the liver and kidney were evaluated. Results: BMI was significantly lower in both the HFD+GUTAC and SD+GUTAC groups compared to the HFD group (P< 0.05). Notably, the SD+GUTAC group exhibited a more pronounced BMI reduction, indicating that combining GUTAC with a standard diet yields greater benefits than its combination with a high-fat diet. GUTAC treatment significantly reduced blood glucose levels (P= 0.0013), liver enzyme activity (AST and ALT), and improved lipid profiles, including total cholesterol, HDL, LDL, and triglycerides, compared to the HFD group (all P< 0.05). Furthermore, GUTAC enhanced renal function markers (BUN and creatinine) and mitigated hepatic steatosis, as evidenced by histological analysis.

Background: Pediatric obesity is one of the most serious public health problems due to high prevalence and negative outcomes. The aim of this study was to estimate the prevalence of Pediatric overweight and obesity and some associated factors among students of elementary school in Yazd- Iran- 2016. Methods: In this descriptive cross-sectional study, a total of 1253 healthy elementary school students were selected by multistage sampling. Body mass index (BMI) was calculated. The diagnosis of childhood overweight and obesity was based on WHO criteria. The parents of the students had the consent to participate in the study. Data analysis was performed by using SPSS version 16 software. Data were reported as mean ± standard deviation or frequency and analyzed by using chi-square test. P-value less than 0.05 were considered statistically significant.

Objective: This study aimed to investigate the effect of 4 weeks of continuous exercise combined with abdominal fat tissue massage on body composition in overweight individuals. Materials and Methods: Twenty-two participants (mean (±SD) age 28(±3) years; BMI 27.5 (±1.7)) were randomly divided into three groups: continuous training (CT, N= 7), continuous training with massage (CT+MA, N= 8), and massage only (MA, N= 7). The massage groups received 15-minute abdominal massages three times a week. The CT+MA group performed moderate continuous training at 50-60% VO2peak for 45 minutes after the massage. The CT group followed the same training protocol without massage. Body composition was assessed before and after the intervention, measuring fat percentage, waist to hip ratio (WHR), abdominal hip circumference, weight, and abdominal skinfold thickness. Results: The PBF, WHR, and skinfold thickness values in the abdominal area of the CT+MA group had a significant decrease compared to MA and CT groups. Conclusion: The results suggest that abdominal massage before exercise enhances lipolysis and spot fat reduction in the massage area, probably by increasing blood supply to subcutaneous fat tissue. This intervention could be a practical approach to boost lipolysis in future research.

Objective: Sodium-glucose cotransporter -2 (SGLT2) inhibitors may improve lipid panels in addition to lowering blood sugar. This research examined how empagliflozin, an SGLT2 inhibitor, affected triglycerides in type 2 diabetes mellitus (T2DM) patients with hypertriglyceridemia. Materials and Methods: This prospective study was conducted at the Endocrinology Clinic of Shahid Rahimi Hospital in Khorramabad, Iran, in 2020. Thirty-eight patients were included using convenient sampling. The patients’ information including age, gender, body mass index (BMI), Fasting Blood Sugar (FBS), Hemoglobin A1c (HbA1c), 2-hour postprandial blood sugar, serum triglyceride, total cholesterol, High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL), serum insulin level, serum creatinine Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Blood pressure, and urine albumin before and three months after receiving empagliflozin 10mg tablets were collected from the clinic medical archives and compared using paired t-test in SPSS software version 22. Results: BMI, microalbuminuria, BUN, FBS, 2-hour postprandial blood sugar, and HbA1c were improved significantly (P< 0.05) after treatment with empagliflozin. In terms of lipid panels, triglyceride, cholesterol, and LDL levels were improved significantly after treatment with empagliflozin (P< 0.05). HDL levels increased following the treatment but the difference was not statistically significant. There was no linear correlation between HbA1c and HDL (P= 0.183) or triglyceride (P= 0.947) levels. Conclusion: Empagliflozin improves triglycerides and cholesterol levels in patients with T2DM in addition to its antihyperglycemic effects. It also reduces BMI, blood pressure, BUN, and microalbuminuria.

Objective: The purpose of this study is to evaluate the potential association between peripheral blood parameters and the morphological characteristics of retinal imaging obtained via spectral-domain optical coherence tomography (SD-OCT) in patients with treatment-naïve diabetic macular edema (DME). Materials and Methods: This cross-sectional study included 100 patients with treatment-naïve DME. All participants underwent spectral-domain optical coherence tomography (Optovue) and fundus photography. Peripheral blood samples were collected to assess complete blood count (CBC), glycated hemoglobin (HbA1c), blood glucose, serum urea, serum creatinine, and lipid profile. Results: Central subfield thickness (CST) was significantly associated with serum HDL (P= 0.003). Intraretinal fluid (IRF) was linked to serum triglycerides (P=0.006), serum VLDL (P=0.001), and cholesterol-to-HDL ratio (P= 0.001). Subretinal fluid (SRF) showed an association with blood glucose (P= 0.028). Hyperreflective foci (HF) were related to total blood count (P= 0.001), monocyte count (P= 0.001), cholesterol-to-HDL ratio (P= 0.045), LDL-to-HDL ratio (P= 0.003), and serum urea (P= 0.051). Disorganization of the retinal inner layers (DRIL) correlated with total blood count (P=0.047), lymphocyte count (P= 0.008), blood glucose (P= 0.007), and LDL-to-HDL ratio (P= 0.046). Epiretinal membrane (ERM) was associated with blood glucose (P= 0.001), total cholesterol (P= 0.022), serum LDL (P= 0.025), cholesterol-to-HDL ratio (P= 0.013), and LDL-to-HDL ratio (P= 0.008). Ellipsoid zone (EZ) and external limiting membrane (ELM) disruptions were linked to blood glucose, serum LDL, and VLDL. Hard exudates correlated with blood cell counts, glucose, HbA1c, urea, and creatinine (P< 0.05). CONCLUSION: Systemic factors are significantly associated with retinal morphological patterns in DME, highlighting the potential for modifying these factors to influence disease progression and treatment response.