Obesity, Diabetes and Gastrointestinal Malignancy: The role of Metformin and other Anti-diabetic Therapy | Author : Michael Ashamalla, Irini Youssef, Mena Yacoub, Apoorva Jayarangaiah, Nikita Gupta, Justina Ray, Sadat Iqbal, Regina Miller and Samy I McFarlane* | Abstract | Full Text | Abstract :The association between Diabetes and cancer has been known for decades with obesity and insulin resistance being postulated as the main underlying risk factors for both disorders. With rise of the epidemic of obesity in the USA and around the globe, there has been a rise in diabetes that is currently reaching epidemic proportions. Diabetes is known to be associated with increased risk of several types of malignancy including breast, cervical, pancreatic and colon cancer. In this review, we discuss the epidemic of obesity and its consequential epidemic of diabetes highlighting the pathophysiologic mechanisms of increased cancer in the diabetic population. We will then discuss the role of insulin therapy as well as other antidiabetic medications, particularly metformin that has been to be associated with lower risk as well as better survival with GI malignancies based on several studies including a study that was recently published by our group. |
| A Review on Associated Diseases, Diagnosis, Treatment and Management of Type 2 Diabetes Mellitus | Author : Adil Omar Bahathiq* | Abstract | Full Text | Abstract :An incidence of diabetes is right away growing everywhere in the world at the startling rate. For the past 3 decades, the prominence of diabetes has been substantially changed, previously it’s been taken into consideration as a minor illness of the aged humans. A gift, it has become the most critical cause of morbidity and mortality affecting the young and center-elderly people. Type 2 diabetes mellitus is an advanced situation wherein the frame become immune to the normal outcomes of insulin and little by little loses the capacity to produce sufficient insulin in the pancreas. It is related to regulating lifestyle with strong genetic and circle of relatives associated hazard elements. This overview is primarily based on associated illnesses like Liver elements, the stiffness of intermediate-sized arteries in patients and cardiovascular disorder. Diagnosis and treatment based totally on numerous metabolic pathways and anti-diabetic retailers, control of sickness with social obligation. There are numerous anti-diabetics pills which might be administered orally or through injection, the synergistic effect of a few tablets would be extra powerful due to the complex components in it. The treatment couldn’t simply be energetic and secure, it ought to additionally enhance the satisfactory of existence. |
| Behavioral therapy in diabetes mellitus and obesity | Author : Istvan Sal* and Ildiko Kohlne | Abstract | Full Text | Abstract :In Weimar, on the wall of Albert Schweitzer Museum, there is a memorial tablet which says: “The purpose of our life is to serve, to show solidarity and helpfulness.” The humanist medical doctor, theologian, philosopher, organist could not have expressed more clearly our confession. Behavioral therapy integrates the cure of body and soul, which occasionally show some duality and opposition. |
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