Abstract :Thrombospondin 1 (TSP-1) as a kind of inhibiting angiogenesis important substances, widely distributed in human tissues, but also makes it occupy the irreplaceable position in the formation of different tissues of tumor, growth, differentiation, metastasis, currently available in the literature about TSP-1 in various types of cancer (such as prostate cancer, bladder cancer, non-small cell lung cancer, breast cancer, cervical cancer, pancreatic cancer, etc.) the occurrence and development of the role of the reported It is often seen. It undoubtedly provides new directions and guidelines for medical science research workers in the field of cancer and its relationship with tumor would has irreplaceable role for prognosis and exploration the clinical tumor’s etiology, diagnosis and treatment. This review is a summary of the discovery and development of TSP-1 in various types of tumor research.