Abstract :SDF has been used for decades in many Asian countries, Australia, and South America as an effective measure of arresting active caries. In 2015, the Food and Drug Administration (FDA) in the US cleared SDF for reducing tooth sensitivity for adults 21 years and older. Professionals can use SDF off-label to arrest carious lesions same as using fluoride varnish to prevent caries. In 2016, a CDT code was approved for caries arresting medicaments to facilitate documentation and billing. Due to SDF’s safe, effective, inexpensive, and simplicity in application, it is considered an appropriate therapeutic agent to prevent and arrest caries use in community dental health programs. We present this review to summarize the mechanism of action, clinical application, uses, advantages, safety and adverse effects, and codes in dentistry.