Abstract :The early detection of chronic kidney disease can prevent damage of kidney as well as myocardial infarction. There are several report which confirm the inter relationship between kidney failure and heart attack. The present paper describes a crucial relationship between kidney glomerular filtration rate and cardiovascular disease risk factors. There are several reported markers and methods for detection of kidney failure are available but all these methods still have some limitations. Biosensors are emerging technology which can predict damage at early stage using electrochemical aptamer technique in which protein binds with specific marker and resulting signals are electrochemically detected as changes in current with respect to control.