Abstract :We case report of a 83 years old male patients with personal history chronic bronchitis, immunosuppressed, leukopenia, operated of prostate cancer and right hemiplegia. He consults with der cay, fever and dyspnea. Respiratory auscultation: abolition of the right breath sounds. Develops a pleural empyema and bacteriemia by Actinomycesodontolyticus and Bacteroides spp. Confirmed by the studies of a laboratory tests, citobacteriologically and culture examination of pleural fluid, x-ray chest and computed tomographic scan of the chest. Are effective treatment for A. odontolyticus and Bacteroides infections with piperacillin/tazobactam and vancomycin, pleural drainage of secretions. Improvement and discharged from the hospital.