Introduction. One of the decisive mechanisms of the influence of xenobiotics on a human organism is the disturbance of calcium-phosphorous homeostasis and oxidative metabolism of cells due to the changes in the intracellular flow of calcium (Ca) and phosphorus (P), their replacement on specific receptors, and subsequent activation of calcium-dependent enzymes and hormones. Even in the case of short hypoxia, and during the action of xenobiotics, prolonged tissue hypoxia occurs, homeostasis of such trace elements as Na+, K+, Ca++, P+++, Mg++, Mn+++, Cu++ and Fe++, that correlates with the decrease of the level of intracellular ATP and the activity of most metal enzymes. Aim. To find out the effectiveness of advanced standard treatment of lesions of the bone system in children from ecologically disadvantaged areas (EDAs) based on the study of calcium-phosphorous homeostasis and mineral density of bone tissue. Materials and methods. We investigated 239 children from ecologically polluted regions and 70 children from ecologically clean area. Children’s age is from 3 to 18 years, sex – 48, 0 % boys and 52, 0 % – girls. Level of calcium and phosphorus in the blood and urine in these children before and after the treatment was analyzed by the biochemistry examination. Bone mineral density and bone system degree of changes were measured by ultrasound densitometry. Results. Level of calcium and phosphorus in the blood in observed children from polluted region was reduced. Level of calcium in the urine was increased in the majority of observed children from the radiation polluted region and in children from the chemistry polluted regions. And level of phosphorus in the urine was increased in the majority of observed children from chemistry polluted regions. The level of the bone mineral density in these children was reduced. Indicators of calcium and phosphorus content in blood and urine and bone mineral density in the examined children after a complex, individually selected treatment were normalized. Indicators of bone mineral density of children from all EDAs irrespective of the nature of contamination and ways of getting xenobiotics into the organism, have significantly decreased and are within the age range compared with the indicators of healthy children after the treatment. Conclusions. In the majority of the examined children in radiation and chemically contaminated areas there was a significant hypocalcemia, hypophosphatemia and hypercalciuria, hyperphosphaturia, which managed to be corrected by the proposed treatment.

Introduction. In the patients with angina pectoris, in case of the iodine deficiency, the metabolism processes, hemodynamics and autonomic regulation can often change. Aim. To find out the peculiarities of the changes of the natriuretic propeptide NTproBNP, diastolic function of the left ventricle and heart rate variability (HRV) in patients with stable angina pectoris in combination with subclinical hypothyroidism. Materials and methods. To understand the features of the clinical signs, the changes of the natriuretic propeptide – NT-proBNP, left ventricular diastolic function and heart rate variability (HRV) in the patients with the stable angina pectoris, combined with subclinical hypothyroidism, 2 groups of the patients were observed: 39 patients with coronary artery disease: stable angina pectoris of II-III functional class (FC) and 44 patients with the stable angina pectoris in combination with subclinical hypothyroidism. In addition to the routine laboratory and instrumental examination methods, the levels of NTproBNP, thyroid stimulating hormone (TSH), triiodothyronine, thyroxine and peroxidase antibody concentrations were determined, also echocardiography, ECG Holter monitoring with providing the heart rate variability testing were performed. Results. The feature of the clinical manifestations of angina pectoris in the patients with the reduced function of the thyroid gland (TG) is frequent attacks of breathlessness and rapid fatigue, meanwhile the anginal pain occurs rarely. Besides, the symptoms of hypothyroidism join and worsen the course of the main disease. The level of the NT-proBNP in the examined patients with angina pectoris and subclinical hypothyroidism is 25,08 ± 0,66 fmol/ml and is significantly higher, compared to the patients with no hypothyroidism (14,24 ± 0,51 fmol/ml) and compared to the control group of the healthy individuals (3,91 ± 0,22 fmol/ml). In the patients with angina pectoris, combined with subclinical hypothyroidism, compared to the patients with isolated stable angina pectoris of the appropriate FC, more pronounced disorders of the left ventricular diastolic dysfunction with more frequent detection of the pseudonormal type are recorded. In the patients with the angina pectoris, combined with subclinical hypothyroidism, the value of TP was 2415,70 ± 37,31 ms2, sympathetic-vagal index was increasing till 2,20 ± 0,04, indicating the decrease of HRV and hypersympathicotonia, meanwhile in the patients with angina pectoris and preserved thyroid function these changes were less pronounced and were 3015,90 ± 38,72 ms2 and 2,07 ± 0,05 respectively. Conclusions. The study of changes of the level of NT-proBNP, the state of cardiohemodynamics and state of autonomic nervous system in patients with angina pectoris in case of iodine deficiency is very important due to the fact that the course of ischemic heart disease is significantly altered – clinical signs of angina are sunken, often symptoms of heart failure are present in the foreground, and this is an important aspect for timely and adequate pathogenetic treatment.

Introduction. In the patients with angina pectoris, in case of the iodine deficiency, the metabolism processes, hemodynamics and autonomic regulation can often change. Aim. To find out the peculiarities of the changes of the natriuretic propeptide NTproBNP, diastolic function of the left ventricle and heart rate variability (HRV) in patients with stable angina pectoris in combination with subclinical hypothyroidism. Materials and methods. To understand the features of the clinical signs, the changes of the natriuretic propeptide – NT-proBNP, left ventricular diastolic function and heart rate variability (HRV) in the patients with the stable angina pectoris, combined with subclinical hypothyroidism, 2 groups of the patients were observed: 39 patients with coronary artery disease: stable angina pectoris of II-III functional class (FC) and 44 patients with the stable angina pectoris in combination with subclinical hypothyroidism. In addition to the routine laboratory and instrumental examination methods, the levels of NTproBNP, thyroid stimulating hormone (TSH), triiodothyronine, thyroxine and peroxidase antibody concentrations were determined, also echocardiography, ECG Holter monitoring with providing the heart rate variability testing were performed. Results. The feature of the clinical manifestations of angina pectoris in the patients with the reduced function of the thyroid gland (TG) is frequent attacks of breathlessness and rapid fatigue, meanwhile the anginal pain occurs rarely. Besides, the symptoms of hypothyroidism join and worsen the course of the main disease. The level of the NT-proBNP in the examined patients with angina pectoris and subclinical hypothyroidism is 25,08 ± 0,66 fmol/ml and is significantly higher, compared to the patients with no hypothyroidism (14,24 ± 0,51 fmol/ml) and compared to the control group of the healthy individuals (3,91 ± 0,22 fmol/ml). In the patients with angina pectoris, combined with subclinical hypothyroidism, compared to the patients with isolated stable angina pectoris of the appropriate FC, more pronounced disorders of the left ventricular diastolic dysfunction with more frequent detection of the pseudonormal type are recorded. In the patients with the angina pectoris, combined with subclinical hypothyroidism, the value of TP was 2415,70 ± 37,31 ms2, sympathetic-vagal index was increasing till 2,20 ± 0,04, indicating the decrease of HRV and hypersympathicotonia, meanwhile in the patients with angina pectoris and preserved thyroid function these changes were less pronounced and were 3015,90 ± 38,72 ms2 and 2,07 ± 0,05 respectively. Conclusions. The study of changes of the level of NT-proBNP, the state of cardiohemodynamics and state of autonomic nervous system in patients with angina pectoris in case of iodine deficiency is very important due to the fact that the course of ischemic heart disease is significantly altered – clinical signs of angina are sunken, often symptoms of heart failure are present in the foreground, and this is an important aspect for timely and adequate pathogenetic treatment.

Introduction. One of the decisive mechanisms of the influence of xenobiotics on a human organism is the disturbance of calcium-phosphorous homeostasis and oxidative metabolism of cells due to the changes in the intracellular flow of calcium (Ca) and phosphorus (P), their replacement on specific receptors, and subsequent activation of calcium-dependent enzymes and hormones. Even in the case of short hypoxia, and during the action of xenobiotics, prolonged tissue hypoxia occurs, homeostasis of such trace elements as Na+, K+, Ca++, P+++, Mg++, Mn+++, Cu++ and Fe++, that correlates with the decrease of the level of intracellular ATP and the activity of most metal enzymes. Aim. To find out the effectiveness of advanced standard treatment of lesions of the bone system in children from ecologically disadvantaged areas (EDAs) based on the study of calcium-phosphorous homeostasis and mineral density of bone tissue. Materials and methods. We investigated 239 children from ecologically polluted regions and 70 children from ecologically clean area. Children’s age is from 3 to 18 years, sex – 48, 0 % boys and 52, 0 % – girls. Level of calcium and phosphorus in the blood and urine in these children before and after the treatment was analyzed by the biochemistry examination. Bone mineral density and bone system degree of changes were measured by ultrasound densitometry. Results. Level of calcium and phosphorus in the blood in observed children from polluted region was reduced. Level of calcium in the urine was increased in the majority of observed children from the radiation polluted region and in children from the chemistry polluted regions. And level of phosphorus in the urine was increased in the majority of observed children from chemistry polluted regions. The level of the bone mineral density in these children was reduced. Indicators of calcium and phosphorus content in blood and urine and bone mineral density in the examined children after a complex, individually selected treatment were normalized. Indicators of bone mineral density of children from all EDAs irrespective of the nature of contamination and ways of getting xenobiotics into the organism, have significantly decreased and are within the age range compared with the indicators of healthy children after the treatment. Conclusions. In the majority of the examined children in radiation and chemically contaminated areas there was a significant hypocalcemia, hypophosphatemia and hypercalciuria, hyperphosphaturia, which managed to be corrected by the proposed treatment.