Abstract :Abstract
Gentamicin is an aminoglycoside antibiotic that has a proven record of effectively treating various Gram negative bacterial infections. The selective accumulation of gentamicin in the renal proximal convoluted tubule results in the induction of nephrotoxicity. Gentamicin-induced nephrotoxicity is characterized by tubular necrosis and glomerular congestion, resulting in decreased glomerular filtration rate and renal dysfunction. In addition, induction of oxidative stress and inflammatory cascades play a key role in gentamicin nephrotoxicity. Numerous pharmacological agents have been identified to have a potential in preventing gentamicin-nephrotoxicity. However, we do not have a promising intervention clinically to blunt gentamicin-nephrotoxicity. Identification of a potent pharmacological intervention to satisfactorily halt gentamicin nephrotoxicity is imperative in clinical point-of-view. However, the effect of corosolic acid in gentamicin-nephrotoxicity is not yet known. Therefore, the present study was designed to investigate the possible effect of corosolic acid (CRA) in gentamicin-induced experimental nephrotoxicity in rats.