Abstract :Abstract
Depression in diabetes contributes to poor metabolic control, decreased quality of life, and increased medical morbidity and mortality. Depression is believed to contribute to the development or progression of diabetic complications through its behavioral and metabolic effects. The main approach of the present study was the treatment of diabeties as well as management in the progression of depression using ethanolic extract of Murraya koenigii leaves (MKL). In the present study diabeties was induced by the intravenous administration of streptozotocin (55 mg/kg i.v.) in male Wister rat and the MKL (300 mg/kg and 500 mg/kg p.o.), standard glibenclamide (10 mg/kg p.o.) were started after 13 days of streptozotocin. While in the second study the effect of chronic treatment of MKL on progression of depression was evaluated after 9 week in streptozotocin (70 mg/kg i.v.) induced diabetic rats.