Abstract :A US author compiled a report on the reasons on the alarming trend of increased deaths due to coronary heart disease (CHD), as well as their implications for patients with schizophrenia indicating that the leading causes of premature death in patients with schizophrenia are suicide (10-fold increase e.g. ˜10% vs. 1%) and CHD (2-fold increase e.g. ˜66% vs. 33%) compared to general population. This increased risk of CHD related deaths can be linked to significantly higher prevalence of risk factors such as smoking (75% vs. 25%), body mass index (BMI) = 27 kg/m2 (42% vs. 27%), diabetes mellitus (13% vs. 3%), hypertension (27% vs. 13%) and metabolic syndrome (41% vs. 22%) compared to general population. This is further complicated by lower access to medications reducing cardiovascular risk compared to general population e.g. dyslipidemia treatment (12% vs. 33%) and antiphypertensives (37.6% vs. 50%). This indicates that the choice of antipsychotic drug therapies of comparable efficacy and a lower likelihood of adversely affecting the major risk factors of CHD is an important consideration for patients with schizophrenia. Further, US veteran affairs study [1,2] revealed that people with schizophrenia (hazard ratio 1.25, P < 0.001) and other psychosis (hazard ratio 1.41, P < 0.001) are more likely to die of CHD than people without mental illness.