Abstract :Abstract
More than a decade ago, the existence of a rare population with both stem cell-like properties and tumor initiating capability was first identified in acute myeloid leukemia and, subsequently, in several solid tumors. These populations with stem cell-like properties were termed ‘cancer stem cells (CSCs)’, indicating that only a subset of cancer cells were tumorigenic and able to initiate and produce the bulk of tumors, thus also termed ‘tumor initiating cells’. In this mini review on issues such as cancer stem cells markers, integrins, Matrix metallo-proteinases, chemokines and chemokine receptors are described to study the cancer stem cells associated metastasis. In this review article, several mechanisms and signaling pathways of cancer stem cells during self-renewal and differentiation were mentioned.