Abstract :Antimicrobial stewardship refers to “coordinated interventions designed to improve and measure the appropriate use of antimicrobials by promoting the selection of the optimal antimicrobial drug regimen, dose, duration of therapy, and route of administration [1].” Hence, antimicrobial stewardship basically aims at helping each patient receive the appropriate treatment without adverse effects of antibiotic use. These programs are beneficial in reducing treatment failures, decreasing health-care associated infections and also reducing antibiotic resistance, while proving economically beneficial to the hospital. Indian hospitals are facing an enormous challenge of managing multi-drug resistant organisms. The major threat is posed by gram negative bacteria which have not only become resistant to third generation cephalosporins, aminogycosides and fluroquinolones but also to carbapenems .This situation has forced the clinicians to use colistin, tigecycline , fosfomycin in various combinations [2].