Abstract :Abstract
DRESS syndrome (drug rash, eosinophilia and systemic symptoms) is an idiosyncratic drug reaction
characterized by rash, fever, lymphadenopathy and internal organ involvement. This syndrome
causes a diverse array of clinical symptoms, anywhere from 2 to 8 weeks after initiating the offending
drug. Many drugs including aromatic anticonvulsants can induce DRESS syndrome. We describe
a case of this syndrome presented to us with fever, rash, eosinophilia and increase platelet counts
after taking lithium. The syndrome resolved with drug withdrawal but co-incidental re-challenge
with lithium, syndrome reoccurred within starting lithium. Prompt diagnosis, withdrawal of the
offending drug and treatment with corticosteroids remain the cornerstone to the therapy of DRESS.
WHO causality analysis scale indicates certain association of this syndrome with lithium.