Abstract :Objective: To assess uterine perfusion early in pregnancy in women with hypovitaminosis D3andevaluate if findings are linked to poor pregnancy outcomes.
Patients and Methods: 300 primigravidae with singleton pregnancy (11weeks to13weeks) were included in this study attending for routine antenatal careat Tanta University Hospitals. Vitamin D3 levels were estimated plus transvaginal color Doppler ultrasound to measure the pulsatility index of the uterine arteries and the spiral arteries.
Results: The mean age of enrolled patients was 26.2±4.593 years, mean BMI was27.64 ± 3.348 and the mean gestational age at booking was 8.54±1.72 weeks. Hundred and fourteen cases out of 300 cases (38%) had hypovitaminosis D3. The cases with hypoperfusion (43 cases) werecomplicated by spontaneous abortion (3 cases), preterm labor (4cases), IUFD (4 cases), hypertension (17 cases), IUGR (7 cases), placental abruption (2 cases). Cases with hypovitaminosis only with normal perfusion was not linked to poor outcomes where only 3 cases suffered late preterm labour after 34 weeks with good neonatal outcomes.
Conclusion: Early uterine hypoperfusion in hypovitaminosisD3 had positive predictive factor in relation to poor pregnancy outcomes while deficiency of Vitamin D only was not related to poor pregnancy outcomes.