Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) is a novel coronavirus responsible for a pandemic that emerged in December 2019. Heterogeneous clinical forms are described from asymptomatic to severe hypoxaemic acute respiratory syndrome with multisystem organ failure. Except for diabetes mellitus, there is no data on the impact of this new virus on the endocrine glands.

50-year-old patient, with no pathological history, no particular medication. Admitted in dermatology consultation, for a small nodule of 1 cm of firm consistency, asymptomatic, sitting opposite the inter phalangeal joint of the third finger of the right hand (Figure 1 (A, B)), in dermoscopy we found on a whitish background, points and tortuous vessels without lipoid deposition at the vitro-pressure, the rest of the somatic examination was without particularity, the interrogation found the notion of arthralgia of inflammatory appearance evolving for 2 years under several analgesics without clear improvement without associated joint deformation.

SARS-cov-2, responsible of COVID-19, is a novel coronavirus which first appeared in Wuhan City (China) in December 2019. The epidemic propagated wildly fast in China first, then to the rest of the world. It is still spreading geographically, contaminating over 5 million people worldwide and is responsible of more than 350000 deaths as of today. A few infected individuals were detected by showing cardiac symptoms such as palpitations or chest pain, rather than respiratory symptoms. The association of Brugada syndrome and COVID-19 is rarely described. We report a case of a patient who presented this association, emphasizing the difficulties of the pharmacological treatment.

Acute Acalculous cholecystitis (AAC) is a potentially fatal gallbladder infection occurring in severely ill patients. Combining it with other serious conditions such as advanced forms of SARS-COV infection19 will worsen the prognosis of these patients. Difficulties in the diagnosis of AAC due to the infectious syndrome overwhelmed by the SARS-COV19-related severe inflammatory syndrome are often encountered. The various stages of medical and surgical management in the intensive care unit and operating room will be impacted by the COVID19 context with the difficulty of respiratory and hemodynamic management of these patients and the precautions to be taken to minimize transmission of the infection.

The coronavirus disease of 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first appeared in Wuhan, China. It was officially declared a pandemic by the World Health Organization in March 2020. Patients with underlying chronic health conditions, mainly hypertension and cardiovascular disease, are at increased risk of developing more severe COVID-19 disease. Pulmonary hypertension (PH) is a pulmonary vascular disease characterized by pulmonary arterial remodeling and vasoconstriction leading to elevated pulmonary artery pressure and, ultimately, right heart failure [1]. So far, there have been only a few reported cases of COVID-19 disease in patients with PH. The authors of this article report a case of a Covid-19 infection and pulmonary arterial hypertension emphasizing its therapeutic and prognostic impact.

Candida spp. colonizes the human host and coexist with members of human microbiome. Candida glabrata are aggressive pathogen, have many virulence factors that lead to serious recurrent candidiasis. Their ability to form complex biofilm, inability to form hyphae and inability to secrete hydrolase lead to antifungal resistance. Candidemia is the fourth most common bloodstream infection [1]. Candidemia remains a major source of mortality and morbidity. Mortality among patients with invasive candidiasis is as high as 40%, even when patients receive antifungal therapy [2]. More than 90% of invasive diseases are caused by the 5 most common Candida spp. C. albicans, C. glabrata, C. tropicalis, C. parapsilosis and C. krusei [3]. The distribution of Candida species has been changing over the last decade, with a decrease in the proportion of C. albicans and an increase in C. glabrata and C. parapsilosis. More than 50% of blood stream infections are caused by non-albicans Candida [4,2]. The largest proportional increase in the USA is in C. glabrata, which accounts for one third or more of all candidemia isolates [5-7]. C. glabrata are associated with high mortality. Candida glabrata develops acquired resistance following exposure to antifungal agents [8]. 50% of C. glabrata are resistant to fluconazole [9,10]. Furthermore, 9% of C. glabrata that are resistant to fluconazole are also resistant to the echinocandins [8,11].

Neoadjuvant chemotherapy is the standard of care in inoperable locally advanced breast cancer (LABC), as it helps in reducing tumor burden and facilitating surgical resection. We describe a 56-year-old post-menopausal woman who presented with a huge, right breast mass extending from the clavicle to the mid abdomen. A chest-abdomen-pelvis computed tomography showed the mass invading the pectoralis muscles and right axillary lymph node with no evidence of distant metastasis. A needle core biopsy revealed an infiltrating ductal carcinoma (Scarff-Bloom- Richardson grade 3). A multidisciplinary collaboration was undertaken, and the patient was started on docetaxel; however, after three cycles of docetaxel, she showed no improvement and was readmitted for palliative mastectomy with skin grafting. A post-operative histopathology examination of the excised tumor revealed an invasive micropapillary carcinoma. A multidisciplinary approach is the cornerstone for the treatment of LABC. In the case of chemoresistance, very few treatment options are available.

Abstract Background: A breast adenomyoepithelioma is an uncommon tumor characterized by the presence of epithelial and myoepithelial cells. Case Report: We describe a 47-year-old woman who presented with a right breast mass of four-year duration. An examination of the breasts revealed two masses in the right inner quadrant of the right breast measuring 1 x 1 cm and 2 x 2 cm in dimension. A mammogram favored a lesion highly suspicious of malignancy, suggesting further examination. An ultrasound examination confirmed the mammography and a biopsy was subsequently performed. A biopsy revealed findings suggestive of duct adenoma. The tumor was excised, and the specimen was sent for histopathological examination. The histopathological findings were consistent with adenomyoepithelioma. The patient was discharged one day after surgery and did not present any complaints. Conclusion: Although most adenomyoepitheliomas have a benign course, it is essential for clinicians to identify these tumors, as the radiologic and cytologic characteristics can mimic malignant lesions. A definitive diagnosis can be made after a histopathologic examination, and tumor excision may be helpful in preventing recurrence or malignant change. Keywords: Adenomyoepithelioma, breast, myoepithelial cells, neoplasm