Cancer of the external genitals is up to 8 % in the overall structure of the incidence of malignant neoplasms of female genital organs. Under our observation there were 92 patients with vulvar dystrophy and suspected cancer. The effectiveness of treatment of vulvar dystrophy (VIN I-II degree) by the method of photodynamic therapy (PDT) 45.8±4.7%. However, dysplasia II - III degree, sclerotic changes with the formation of pronounced horn scales prevents the full PDT and recurrence of the disease. Reconstructive plastic surgery was performed using cryoapplication and « Harmonic» apparatus to reduce blood loss and duration of lymphorrhoea in the postoperative period. The use of new reconstructive plastic surgery, including with the use of abdominal skin and fascial flap combined with vascularized lower segments of the rectus muscles), have helped to reduce complications, improve cosmetic effect (patent for invention ? 2580665 from 11.11.14).

Background: Pregnancy-related pelvic girdle pain (PPGP) represents a common condition with implications for persistence. Currently, a practice gap appears to exist related to the assessment and management of pregnancy-related PGP. This study explored Irish physiotherapists’ perspectives of PPGP. Methods: A survey from previous Canadian research was adapted and used to determine Irish physiotherapist’s perspectives regarding PPGP. Women’s health physiotherapists, private and public sector, were invited to complete an electronic survey. Results: Sixty of the 122 invited physiotherapists completed the survey for a response rate of 49%. Of these, 98% agreed that relevant health care providers need to be able to recognize a PPGP presentation, and 80% believed PPGP to be a complex clinical presentation requiring early detection and associated care. The vast majority of perspectives related to etiology and treatment focused on musculoskeletal influences, however addressing fear (84%) and employing pain neuroscience education (82%) were also indicated to be very important. Conclusion: Pregnancy-related PGP is a distinct presentation of PGP impacting women in the perinatal period and beyond differs in etiology due to perinatal and associated biopsychosocial influences. Irish physiotherapists perceive a number of important evolving psychosocial characteristics of PPGP, however unsubstantiated strong perspectives related to biomechanics and pelvic stability were also found. Knowledge translation efforts to support the provision of evidence-informed care are needed.

Many molecular markers have been identified in different stages of the luteal phase those play roles in the implantation. Our aim was to compare the levels of insulin-like growth factor binding protein 1 (IGFBP-1), Osteopontin (OPN) and prostaglandin E2 (PGE2) in endometrial washing liquid between women with ovulatory polycystic ovary syndrome (PCOS), endometrioma and unexplained subfertility, compared with ovulatory women. The study groups were formed by women with ovulatory PCOS (n=24), endometrioma (n=17) and unexplained subfertility (n=25). The control group consisted of fertile women (n=18). There were no significant differences in terms of the values of IGFBP1, PGE2 and OPN among groups. There was a statistically significant difference between ovulatory PCOS group and control group in terms of PGE2 levels (p=0.002). High PGE2 might be a marker for poor endometrial receptivity. We supposed that the down-regulation of PGE2 may facilitate decidualization and improve pregnancy rate in ovulatory PCOS.

This prospective observational study was conducted on 220 patients with polycystic ovary syndrome (PCOS) and subclinical hypothyroidism (SCH) who were allocated into two groups; group one (n=112) received clomiphene citrate (CC) plus thyroxine while group two received only CC for ovulation induction. Patients receiving CC and thyroxine exhibited higher ovulation rate (p<0.001), higher endometrial thickness (p<0.05), higher number of dominant follicles (p<0.001) and higher pregnancy rate (p<0.001) compared to their counterparts receiving only CC. Thyroxine supplementation improves ovulation and pregnancy rates in infertile patients with PCOS and SCH receiving CC for ovulation induction who are therapy naïve.

Caffeine is widely consumed by both men and women but its pharmacological effects have not been well studied in the area of assisted reproduction. Various authorities indicate that caffeine consumption up to 400 mg per day is safe, but caution is advised for women who are, or are contemplating pregnancy and they should keep their intake under 200 mg per day. Our lifestyle studies at Curtin University showed adverse effects from caffeine consumption in both men and women. For men, fertilization rates were negatively associated with caffeine consumption (P<0.05) as well as IVF-related stress (P<0.005). Furthermore, caffeine negated the beneficial effect of male alcohol consumption, comprising mainly beer, on fertilization. For women, fertilization rates were negatively associated with caffeine consumption (P<0.005) and smoking history in years (P<0.001). However, our studies could not show any effect of caffeine consumption on the chance of pregnancy or miscarriage up to week 12 from either male intake (up to 4495 mg per week) or female intake (up to 2706 mg per week). We conclude that there is likely to be an effect from caffeine on one-Carbon metabolism and future studies need to interrogate the concomitant nutritional intake of B-vitamins and serum homocysteine levels, which can indirectly indicate deficiency or interference with this important metabolic pathway.