Introduction: Adolescence constitutes one of the most important transition stages in life and is characterized by changes representing a stage of vulnerability. Teen pregnancy is one of the most important medical dilemmas, Uruguay considered reducing it in the framework of the "2020 National Health Objectives". Objective: to describe the percentage of births, repetition of pregnancy and Voluntary Interruption of Pregnancy (IVE) in the adolescent population using the Montevideo-Uruguay Clinic Hospital between 2009-2017. Material and methods: observational, descriptive, retrospective study. Results: 1,574 births were in adolescents (24.02%). 29.8% occurred in users with previous pregnancies and 19.1% had at least one child alive. 19.18% of the IVE were in adolescents. Discussion and conclusions: There is a stagnation of the percentages of the parameters analyzed in these years. Teen pregnancy and its repetition constitute a failure of health policies in sexual education and it is necessary to increase our efforts to reduce them.

Emergence of various Nano scale drug carrier platforms as Drug Delivery Systems (DDS) has revolutionized the field of medicine. Nonetheless, the side-effects due to non-specific distribution of anticancer therapeutics in normal, healthy tissues remain to be a prime pitfall in curing cancers. Therefore, to achieve a better therapeutic efficacy, the use of a target-specific delivery, combined with a stimuli-responsive Nano carrier system, particularly pH-sensitive Nano systems offer an attractive strategy. Targeted drug delivery through pH-sensitive Nano systems offer the potential to enhance the therapeutic index of anticancer agents, either by increasing the drug concentration in tumour cells and/or by decreasing the exposure in normal host tissues. Therefore, Nano scale-based drug delivery through pH-sensitive Nano systems seem to be a boon for treating gynaecological cancers (as well as other cancers) without side-effects or with least harm to normal healthy tissues.

Vulvar cancer is rare, occupies the fourth most common type of gynecological cancer mainly affects postmenopausal, there are no screening tests or effective strategies to reduce its incidence, only the timely treatment of preneoplastic lesions; It is initially asymptomatic, chronic pruritus or vulvar pain is reported, or the presence of tumor or ulcer; alone, the biopsy confirms the diagnosis and histopathological type. Surgical staging involves the removal of the primary lesion and locoregional lymph node evaluation. In current practice, surgical management is conservatively substituted for radical vulvectomy and depends mainly on the histopathological type and staging, mainly the nodal state. Conclusion: The treatment of malignant neoplasms of the vulva, in general, surgery is the primary treatment.

Pregnancy is a special event in women’s life, as it is unique for the mother child binominal. Maternal and neonatal morbidity and mortality remain unacceptably high, despite a focus on improving the health of pregnant women and newborns through Millennium Development Goals 4 and 5. The main aim of this study is to identify the level of knowledge on preparation and management of labour among primigravida women in the age group of 20-35 years. A pre experimental one group pre test and post test design was selected and purposive sampling technique was adapted to recruit the sample. The sample size was 30. Tools like demographic variables, structured interview schedule and structured teaching programme on preparation and management of labour were used. At the first day, pre test was conducted and structured teaching on preparation and management of labour was administered for group of antenatal women. After one week post test was conducted by same tool. Data analysis was done by using both descriptive and inferential statistics. Majority (50%) of the women were in the age group of 21-25 years. The overall mean score in pre test was 12.16±4.4 and the mean percentage was 40.53. In post test the overall mean score was 22.76±7.26 and the mean percentage was 75.87. The calculated ‘t’ value is 10.18 at 0.05 level of significance. It depicts that structured teaching on preparation and management of labour was highly effective. There was no significant association between the demographic variables of primigravida women and the pre and post test knowledge scores.