The COVID-19 Pandemic and its consequences illuminates the globalization of the crisis but also differences and discrepancies in reporting the data as well as in their interpretations. From the outset the magnitude of the problem and its spread were assessed according to political interests. Public-Health responses were also implemented according to politics and compliance has been linked to communities` and individuals` preconceived social biases. It is apparent that “the numbers do not speak for themselves”-they are filtered, amplified or suppressed, through the megaphones of their reporters. Truth is in the eyes of the beholder.

Vision problems with sudden in onset points towards the neurological deficit because of underlying acute attacks like stroke, or de-myelinating disease. While these problems are common, the viral infection particularly, novel corona virus, SARS-CoV-2 infection in current situation, should also be kept in physician’s mind and dealt accordingly.

Familial CreutzfeldtJakob disease (fCJD) is caused by mutation in PRNP gene. The D178N variant of CJD is known to have phenotypic variability and can often mimic other neurological disorders. In this article, we report a family with D178N variant of PRNP mutation with phenotypic variability and anticipation phenomenon.

Coronaviruses comprise a large family of viruses, many of which cause illnesses in humans and animals. The coronavirus responsible for the current pandemic SARS coronavirus 2 (SARS-CoV-2) started in Wuhan, China, and then spread worldwide.In a few weeks, more than a hundred thousand cases and deaths were confirmed globally and these numbers kept increasing exponentially. The WHO on March 11, 2020 declared the COVID-19 outbreak a global pandemic. Worldwide, nations tried to halt the pandemic by testing, tracing contacts, limiting travel, quarantining, cancelling large meetings and events, and most importantly, imposing lockdowns [1].Lockdown refers to government-placed and government-enforced restrictions on the movement of citizens, outside their houses. A total lockdown was imposed in India on March 24, 2020.

Background: Cerebral hemiatrophy or Dyke-Davidoff-Masson Syndrome is caused by developmental hypoplasia or acquired atrophy of one cerebral hemisphere and leads to diverse clinical entities. In most cases, diagnose is made upon childbirth or during childhood period. Case: We present a case of 30 years old woman who was admitted to our Clinic of Neurology with left-sided hemiparesis and a history of epileptic seizures during her childhood as well as perinatal hypoxia and reanimation after childbirth. Her magnetic resonance imaging exam showed right cerebral hemiatrophy. Further on, we discuss etiology, radiological morphofunctional findings and cognitive impairment in the patient with DDMS.

From time immemorial, philosophers and theologians struggled to describe how mental states emerge from the operations of the brain.Our own efforts have been focused on memory and emotive states. We define the words: “Mentation”, “sensation” or “feelings”, “emotions”, “memory” and “mind”. In particular, we distinguish between computer memory and neural memory, the former being “demotive”, the latter imbued with emotive qualities. Feelings are sensations linked to psychic states; Emotions are the recall of feelings.

Introduction: Multiple sclerosis (MS) is an auto-immune disease which involves an abnormal response of the body’s immune system directed against the central nervous system (CNS) - brain, spinal cord and optic nerves being involved. Suicide is defined as the act of killing yourself, most often as a result of chronic conditions. Objective: The study aims to gain insight into the presence of suicidal ideations among Persons with Multiple Sclerosis and the effect of the same on their Quality of Life. Methodology: To achieve the purpose of the study, the patients presenting to the Multiple Sclerosis clinic of Department of Neurology were assessed using the Multiple Sclerosis Quality of Life Scale (MS-QOL), Expanded Disability Status Scale (EDSS) and the Scale for Suicide Ideation (SSI). Based on the assessment individualized interventions were carried out focusing on their perception, precautions and the necessary preventive strategies to be taken.

Background: The COVID-19 pandemic has affected everyone’s life in all aspects. It presents an unprecedented challenge to public health. Doctors and other healthcare providers are battling the virus on the frontline. Objective: This study is to see the mental health conditions of doctors in Bangladesh during the COVID-19 pandemic as well as to identify the percentage of doctors who are at high mental health risk and thus, need clinical intervention. Method: We have assessed the mental health of 358 Dhaka-based doctors applying ‘General Health Questionnaire-12’ in an online survey.

The Covid-19 pandemic is causing serious fear of falling sick, dying, helplessness and stigma. Such diseases have had a negative considerable influence on every aspect of society of any given nation. Although depression is a commonly occurring global mental health disease, research concerning tools and strategies for early detection, prevention and treatment has not yes focused on the possible utilisation of measures of Emotional Intelligence (EI) as a potential predictive factor impacting depression. The present study investigated the correlation between the construct of EI and the depression during Covid-19 pandemic. A population sample of 141 outpatients (57% female) have completed self-report instruments assessing EI and depression.

Introduction: We investigated the relationship between lateralization indices based on the of Brodmann areas (BA) connectivity and language fMRI paradigms in a group of children with intractable epilepsy. Methodology: Intrahemispheric ROI-to-ROI connectivity was assessed in 36 epileptic children (24 females) mean age 15.3 years, utilizing resting-state fMRI. Left vs right asymmetries were investigated between (1) BA pairs (pair-wise connectivity: PWC); (2) BA modules (global BA module connectivity: GBA); and (3) cerebral hemispheres (global hemispheric connectivity: GHC). Connectivity strength was graded in T scores (Z normalized values). Lateralization Index (LI) scores based on T values were obtained in all three assessments. Only LI with 2 SD above the mean were considered as significant lateralized pairs. Additionally, simple algebraic difference between left and right T values were obtained (TDIF).

Placebo reaction is a relief of symptoms based on using medically inactive substances or procedures. It seems that a human brain has innate capability of restituting wellbeing according to motivation to regain health and preserve one’s life. Brain- mind responds to informational context around the placebo treatment rather than the substance itself. Rituals around healing procedures stimulates human mind and this stimulation activates cascade of neurochemical processes which involve opioids and dopamine. Ac-tivated prefrontal cortex elicits reactions in neurovegetative system and hormonal axis which are both connected to immunity and other bodily functions.

Over the past decades, the administration of probiotics has gained much attention. As per the definition of probiotics by WHO, these are living microorganisms used for the management of various diseases [1]. In the market various strains of probiotics are available. Depends on the properties of these probiotics stains they are used in the management of various diseases. Probiotic plays an imperative role in the prevention of ulcerative colitis. Probiotics guard the intestinal mucosal layer against the attack of microbes. Additionally, it also serves as immunoglobulins. Probiotics also having anti-oxidant and inflammatory properties.

Penicillamine can cause various cutaneous adverse effects. Elastosis Perforans Serpiginosa (EPS) is a rare complication of long-term penicillamine therapy. We report a case of 21 year old male patient, diagnosed as a case of Wilson’s disease 10 years back, and taking D-penicillamine for last 10 years. Now, presented with non-itchy skin lesions over the neck region and bilateral axillae. Skin biopsy showed the presence of abnormal elastic fibers surrounded by acanthotic epidermis compatible with the diagnosis of elasto-sis perforans serpiginosa (EPS). EPS is a rare complication of long-term penicillamine therapy causing transepidermal elimination of abnormal elastic fibers.

Purpose: Levetiracetam (LEV) is a safe and effective drug to control status epilepticus (SE) or refractory status epilepticus (RSE) in adults. However, there is discernible lack of evidence of its use in children and adolescents. There is dearth of randomized trials comparing its efficacy with sodium valproate (VPA) in children. We performed an open randomized study to determine efficacy of LEV as an alternative to VPA in treatment of RSE.Methods: We randomized 80 children aged 1 to 16 years with SE not responding to any two of the first line drugs in adequate doses, into two drug groups LEV (n = 40) and VPA (n = 40). Primary end point was cessation of seizure activity within 30 minutes. Response of the two drug groups were compared at 30 minutes, 24 hrs, discharge and one month follow up.