Background: Coronary Artery Disease (CAD) is a worldwide public health problem. Its prevalence rate is increasing all over the world including Egypt. Aims: To determine the socio-demographic, lifestyle, medical and psychosocial risk factors of CAD among elderly Egyptian patients, and to determine patients’ candidates to cardiac surgery. Patients and Methods: A case-control, hospital-based study design was chosen to conduct this research. The study was conducted on 120 patients with CAD and an equal number of controls. The patients and controls were subjected to an interview, and clinical and laboratory examinations. Results: The important significant risk factors for CAD were male gender, widow/widower, high education, profession occupations, high social class, smokers, physically inactive, high fat and salt intake, hypertension, diabetes, metabolic syndrome, chronic kidney disease, obesity, abdominal obesity, family history of CAD, stress especially general stress, depression, anxiety, aggression, absence of social support, and high levels of TG, total cholesterol, LDL-cholesterol, and low HDLcholesterol levels (OR=4.27, 5.54, 3.06, 3.29, 2.07, 3.56, 2.49, 4.42 & 3.97, 6.44, 5.5, 4.66, 2.88, 4.38, 5.7, 4.03, 3.33 & 4.96, 3.21, 10.47, 5.03, 3.14, 3.68, 4.46, 4.88, and 7.66; respectively). Conclusion: CAD is an important preventable health problem as many of its risk factors are modifiable. Modifications of lifestyle and psychosocial risk factors of CAD are the most important interventions to reduce morbidity and mortality of CAD. Recommendations: It is important to pay more attention to increase people’s and health care team’ awareness about these modifiable risk factors. This could be achieved through health education programs. Also, routine screening of subjects above age of forty for early detection of medical risk factors and psychosocial upset for better prevention and control of CAD is recommended.