Efficacy of a single fixed 131I dose of radioactive iodine for the treatment of hyperthyroidism | Author : Husain Taha Radhi | Abstract | Full Text | Abstract :A total of 135 patients were treated for hyperthyroidism with 131I 15 mCi radioiodine ablation. The therapeutic target was achieving hypothyroidism.
Between January 2014 and December 2018, clinical records were reviewed and date was collected and reviewed for 135 patients with hyperthyroidism that were referred to the Nuclear Medicine Department at Salmaniya Medical Center, for radioactive iodine (RAI) thyroid gland ablation procedure for definitive treatment of hyperthyroidism.
About 39.7% of our patients achieved response between 4-6 months out of which 35.7% of the patients showed response in the first 3 months. 21.4% of the patients took between 7-12 months to show response and only 3.2% responded after 12 months. The most significant response was hypothyroidism comprising of 94.4%. It is also worth mentioning that 4.0% of patients achieved euthyroidism and did not require any follow-up medication.
Using fixed dose of RAI of 15mCi for treating various type of Hyperthyroidism, successful treatment with a single dose of RAI can be achieved in 92.7% of the patients, with first therapy failure rate in 7.3%, with few patients requiring additional doses of RAI. |
| Tamsulosin and Dementia in Old Age: is There Any Relationship? | Author : Irami Araújo-Filho | Abstract | Full Text | Abstract :Tamsulosin is used to treat Benign Prostatic Hyperplasia (BPH), prescribed annually to about 12.6 million patients worldwide. It is an alpha-adrenergic antagonist that reduces the tone of the prostate smooth muscle involved in the pathophysiology of BPH. By acting on alpha 1A receptors, predominant in the prostate, tamsulosin also acts on receptors present in the brain. This study consisted of a literature review aimed at disseminating scientific knowledge about the relationship between the use of tamsulosin and the onset of dementia. Pubmed, Scopus, Scielo, Embase, and Web of Science studies involving dementia in patients using tamsulosin in the last five years were selected. The review showed a risk correlation and a higher incidence of dementia in treated patients. The risk ratio, when compared to other medicines, approached 1.20. In conclusion, it was identified the need for clinical trials with higher sampling power to increase relational significance due to the high prevalence of BPH and the extensive use of tamsulosin in elderly patients with the disease. |
| Introducing S.A.M.S | Author : Seun Ayoade | Abstract | Full Text | Abstract : Conventional medicine is based on the Germ Theory. Alternative/complementary forms of therapy include acupuncture, aromatherapy, chiropractic, homeopathy, naturopathy, osteopathy, reflexology, ayurvedic, and reiki. The Germ-Terrain duality theory of disease states that the etiology of certain diseases/diseased states is better explained as a complex interplay between germs and the inherent anatomical/physiological integrity of the body cells. It argues that the etiology of certain diseases is not fully explained merely by the presence of germs (Germ Theory) or by a mere loss of cellular integrity (Terrain Theory). As a result, the prevention and treatment of such diseases should focus not just on fighting germs but on maintaining/restoring anatomical/physiological cellular integrity. The Germ-Terrain duality theory is a harmonization of the current Germ Theory (popularized by Louis Pasteur) and the hitherto discarded Terrain Theory (popularized by Pierre Bechamp). |
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