Present study was aimed to evaluate the anti-diabetic efficacy of Ficus glomerata in Alloxan monohydrate induced albino rats. Oral administration of fresh Ficus glomerataleaves (2 - 4 g/day) for 60 days shows significant blood glucose lowering effect in experimental alloxan induced diabetic rats. These diabetic rats blood glucose level became normal when fed with Ficus glomerata leaves. It is amply revealed that fresh Ficus glomerata indica leaves possessed anti-diabetic properties. The results suggest that statistically significant anti-diabetic potential in alloxan monohydrate induced diabetic rats. The Ficus glomerata leaves to be almost similar effect like insulin treatment in alloxan monohydrate administered animal model. From the present investigation it appeared that Ficus glomerata leaves might have some ingredients to increase the output of insulin by binding to the receptors of the Beta cells of the Langerhans located in the pancreas. Once they bind to the Sulphonyl urea receptors, the K+ -ATP channels are probably closed and therefore the membrane is depolarized and insulin production is stimulated.

Interruption or lack of sleep has been linked to chronic degenerative diseases including obesity, which has tripled its figures worldwide in the last 40 years according to data from the world Health organization (WHO). Obesity associated with lack of sleep affects the Circadian rhythm which is responsible for synchronizing the energy balance during the sleep- wake cycle, hormonal secretion, homeostasis of food/energy, among the others. The aim of the study was to determine plasma levels of acylated ghrelin in obese young adults with sleep deprivation to plasma levels of acylated ghrelin in obese Young Adults. Study was carried out a total of 56 young adults with obesity, one of the groups had the condition of lack of sleep, n = 28 per group, to determine the relationship between hours of sleep levels of acylated ghrelin Spearmans correlation test was applied, a negative correlation of Rho = -0.293 and p = 0.028 was found the results obtained suggest that lack of sleep may be a factor that alters hormonal regulation and promotes obesity.

Obesity is one of the major problems facing human beings at present. Because of the consumption of refined sugar and foods rich in carbohydrates, as well as adoption of a more sedentary lifestyle (often by necessity as is the case with most office workers), people in all countries are increasingly getting obese, which in turn is leading to other disorders like diabetes and cardiovascular complications. Existing conventional drugs have adverse side-effects, which is the major cause for scientists to look towards the plant kingdom for discovery of newer drugs with less or no side-effects. The Allium genera of plants are widely known for their medicinal properties, in particular Allium cepa (onion) and Allium sativum (garlic), whose beneficial actions include anti-obesity effects. In this mini review, we examine a lesser known plant of the Allium genera, namely Allium fistulosum L. and review its anti-obesity potential. The conclusion of the present study is that the plant contains phytochemicals like ferulic acid and quercetin, which possess anti-obesity mechanisms of action thus rendering the plant to be of potential use against obesity.

Diabetes affects millions of people worldwide and is a leading cause of amputation, blindness, neuropathy, and chronic kidney disease. Chronic kidney disease results in the prolonged impairment of kidney function. Common medications and lifestyle modifications do not eliminate the long-term complications of diabetes, because they lack the ability to restore the periodic cycle of insulin that exists in healthy physiology. Our study used a precise administration of exogenous insulin, mimicking the physiologic profile of insulin secretion, which is more effective at stabilizing cellular blood glucose uptake and reducing diabetic complications than current drug and lifestyle modifications alone. In this case study report, we evaluated three diabetic or pre-diabetic patients who showed improvements in kidney function after beginning this treatment modality. We monitored their chronic kidney disease symptoms before and after the physiological insulin resensitization (PIR) process. We showed that the patients improved in kidney function after several months based on their laboratory metrics and CKD stage classification.

Lipids are a major component in the process of SARS-CoV-2 infection. The clinical significance of plasma lipid profiles during COVID-19 has been described in several studies to date. The purpose of this mini-review is to summarize previous research studies regarding the association of plasma lipid profile with the clinical severity of SARS-CoV-2 infection. This edition presents mini-review reports on research studies related to LDL and TG levels that can predict severity in patients with COVID-19. Atherogenic dyslipidemia that occurs during infection is reported to be very strongly correlated with a more severe prognosis in COVID-19 infection. Therefore, lipid profiles should be performed to indicate acute and measurable inflammation in COVID-19 patients, and fish oil and statin therapy should also be considered to improve the condition.