Nonalcoholic fatty liver disease (NAFLD) is a growing disease globally. It is strongly related to obesity and insulin resistance. NAFLD poses a public health issue because it may progress to NASH and subsequently to cirrhosis [1]. Currently, NASH cirrhosis is going to be the second most common cause for chronic liver disease in adult patients awaiting transplantation [2]. There is evidence that its prevalence is also increasing in children which creates an urgent need to identify patients with NAFLD and intervene early.

Megacystis Microcolon Intestinal Hypoperistalsis Syndrome (MMIHS) is a rare congenital anomaly that is considered the most severe form of functional obstruction of the gastrointestinal tract. This devastating condition is composed of non-obstructed urinary bladder, microcolon with decreased or absent intestinal peristalsis. This study was designed to describe the incidence and outcome of MMIHS.

The gallbladder hypoplasia is a rare congenital anomaly. We present a case of a 38-year-old man who was referred to us for surgical management of gallbladder disease. The patient presented abdominal pain compatible with repeating biliary colic as the first clinical manifestation. Preoperatively, the magnetic resonance cholangiopancreatography imaging was useful to study thoroughly the biliary tract in order to avoid any iatrogenic injury. Intraoperatively, laparoscopy revealed a rudimentary gallbladder and the histopathological examination confirmed the diagnosis of hypoplasic gallbladder. Laparoscopic cholecystectomy was successful and the patient did not present abdominal pain again.

Endogenous fragments of p53 identified recently in human cytomegalovirus (HCMV)-infected human lung fibroblasts, specifically a ~44-kDa N- terminal fragment referred to as p53(?Cp44), have been shown to be generated via m-calpain cleavage. p53(?Cp44) appeared to be tightly associated with a chromatin-rich fraction, and was stabilized by the proteasome inhibitor MG132, particularly in mock-infected cells. The N- terminal p53 fragments were also present in three human dermal fibroblast cell lines tested, including fibroblasts isolated from post-burn hypertrophic scar. Understanding the biological functions of these fragments in the regulation of physiological and pathological processes, and the mechanisms regulating their generation and degradation, may shed light on currently unrecognized aspects of p53 regulation and function, and may provide a pathway for drug discovery.

The objective of the current investigation is to formulate ethyl cellulose and hydroxypropyle methyle cellulose based sustained release microspheres, containing lansoprazole as model drugs. lansoprazole is type II anti-ulcer agent when administered shows synergetic effect in their action. Microspheres were prepared by W/O/O double emulsion solvent evaporation method with different stabilizer concentration and at different speeds of emulsification while maintaining constant amount of lansoprazole. Drug excipient compatibility study was performed prior to formulation development and only compatible excipients were used in the fabrication of microspheres. Prepared microsphere formulations were characterized by percentage yield, particle size analysis, entrapment efficiency, invitro release behavior, differential scanning colorimetry (DSC) and scanning electron microscopy (SEM). SEM studies showed that the microspheres were spherical with rough surface morphology. The drug loaded microspheres showed 10.4-57.9% entrapment capacity for lansoprazole and The invitro release profile showed a slow and steady release pattern for lansoprazole. A 95-98% was releases within a period of 12 hrs . The drug release was found to be diffusion controlled mechanism. The n value of Korsmeyer Peppas equation indicated non Fickian type of diffusion.