More than “usual” pregnancies adequately followed up and with precise scheduled timing, other pregnant women reach our outpatient services.

Background: Preterm birth(PTB) is a primary cause of neonatal morbidity and mortality, the pathogenic mechanisms of PTB still remain largely unexplored. In the present study, we aimed to identify potential key genes and pathway associated with PTB by bioinformatics analysis. Methods: The GSE46510 dataset was obtained from GEO database. Differentially expressed genes (DEGs) were identified using the limma package in R software, the functional enrichment analysis was performed, and the protein-protein interaction (PPI) network was constructed by Cytoscape software. The network topology was analyzed using MCODE. Results: A total of 335 DEGs were identified from the dataset. The majority of up-regulated DEGs were significantly enriched in inflammatory response, while down-regulated DEGs were mainly enriched in mitotic nuclear division. The top 5 hub up regulated genes were ITGAM, IL1B, ITGAX, NFKB1, and SOCS3. Pathway analysis indicated enrichment in Cytokine-cytokine receptor interaction, signaling by Interleukins. The top 5 hub down regulated genes were CXCR4, ANAPC10, ANAPC4, UBE2V2, UBA3, Pathway analysis indicated enrichment in Ubiquitin mediated proteolysis, Phosphorylation of the APC/C. Conclusion: Our study indicated genes and pathways in PTB by bioinformatics analysis, which may provide novel insights for unraveling pathogenesis of PTB.

Background: During the first 36 to 38 weeks of normal gestation, the myometrium is in a preparatory yet unresponsive state. Concurrently, the cervix begins an early stage of remodeling yet maintains structural integrity. Induction of labour is a complex process involving cervical ripening which undergo extensive remodeling and dynamic changes controlled by hormonal, inflammatory changes, and other biological processes. Aim of the Work: to assess the effect of intravenous administration of dexamethasone on the induction delivery interval in term patients with prelabour rupture of membranes undergoing induction of labor. Patients and Methods: This randomized control trial was conducted at department of Obstetrics and Gynecology at Ain Shams University Maternity Hospital (ASUMH) in the period between August 2020 and January 2021. Participants of this study were 80 full term pregnant women with pre-labor rupture of membranes attended the labor ward in El Demerdash Maternity Hospital and scheduled for induction of labor by 8 mg dexamethasone IV before starting induction by PGE1, after 4 hours oxytocin was added by 1 IU/hr with the dose increasing by 1 IU every 30 minutes till optimal contractions were reached which were three uterine contractions in 10 minutes and each lasting for 40-50 seconds. Results: Fetal distress, arrest of delivery and indications of CS delivery were non-significantly less frequent among Dexamethasone group. Induction-active phase and active phase durations were significantly shorter among dexamethasone group than among control group. Second and third stages durations were non-significantly shorter among dexamethasone group than among control group. Total induction-delivery duration was significantly shorter and rate of vaginal delivery was significantly higher among dexamethasone group than among control group. Postpartum hemorrhage (PPH), postpartum endometritis, chorioamnionitis were not reported among the studied groups. No significant difference between Dexamaethasone and Control groups regarding neonatal condition Conclusion: Intravenous administration of dexamethasone in addition to labor induction protocol shortened the induction - active phase and active phase durations. It shortened the total induction-delivery duration and increased the rate of successful vaginal delivery. It has no effect on second and third stages durations with no increase in incidence of intrapartum, postpartum nor neonatal complications.

Objectives: The aim of this study is to evaluate the association between changes in C reactive protein and pregnancy rate in IVF/ICSI. Patients and methods: A prospective cohort study that was conducted in Ain Shams University Maternity Hospital, Infertility Clinic during period time from September 2018 to September 2020. A total of 100 infertile women who were candidate for IVF/ICSI, over a period of 2 years, beginning in September 2018 were recruited to the study after they met the inclusion and exclusion criteria. The participants gave written informed consent and approval for the ethical aspects of the study. Results: This study showed no statistically significant differences according to clinical pregnancy regarding the sociodemographic data as BMI, duration of infertility and type of infertility and regarding Oocyte retrieval and embryo transfer, also no significant differences according to clinical pregnancy regarding CRP at baseline and at Oocyte pickup as well as CRP change at oocyte pickup. But age was significantly lower in cases with clinical pregnancy and CRP at embryo transfer and CRP change at embryo transfer were significantly higher in cases with positive pregnancy. Conclusion: Finally, we concluded that patients whose CRP level decreased on transfer day, had lower chance of pregnancy, whereas patients whose CRP level elevated on embryo transfer day had high chance of pregnancy

Introduction: Anemia is a public health problem, prevalent among women of childbearing age. The aim was to determine the frequency of anemia in the first, second and third trimesters of pregnancy and to determine the associating factors in Algerian pregnant women. Methods: We conducted a prospective and longitudinal cohort study of 300 pregnant women from December 2013 to July 2016. All consenting women attending antenatal clinics and having undergone complete blood count (CBC) were included in the study. Sociodemographic characteristics, individual’s obstetrical history and the results of the CBC were collected. Anemia was defined according to the WHO criteria. After some descriptive statistics, we performed a bivariate analysis using the Chi-square test and Fisher exact probability test in order to determine the factors associated with gestational anemia. Results: The rate of anemia was 28.0 % in the first trimester, 32.3 % in the second and 54.2 % in the third one. It was more frequently observed during the third trimester of pregnancy (P < 0.05). No significant difference was found between gestational anemia and socio-demographic factors. Women with inadequate gain were more anemic (p = 0.01). The average concentration of hemoglobin, hematocrit, VGM and platelets were lower in anemic pregnant women (p < 0.0001). Conclusion: The prevalence of anemia during pregnancy remains high. A better management of chronic diseases in pregnant women and of postpartum follow-up is necessary to treat anemia before a subsequent pregnancy.