Otocephaly is characterized by aplasia or hypoplasia of mandible, a small oral fissure and low lying ears at the level of neck usually meeting in the midline. This is due to the failure of migration of the ventral part of the first brachial arch. This rare lethal non familial condition occurs in 1 in 70,000 births. This is the first reported case of otocephaly in Tema city, Sohag governorate, Egypt as per our best knowledge, a baby girl born to non-consanguineous parents, who was unable to survive a long time after birth. This case is being reported because of its rarity.

Warthin tumor (WT) is a benign epithelial tumor of the salivary glands. It is ranked second after the pleomorphic adenoma. The tumor is characterized by the slow evolution and painlessness but without treatment, it can reach important dimensions. Optimal treatment of Warthin’s tumor is controversial, hereby we describe a case of giant Warthin tumor diagnosed in 78 year men and treated by total parotidectomy with preservation of the facial nerve.

Recently, a cluster of cases of pneumonia has outbroken and spread rapidly in Wuhan, China. Chinese health authority conformed that it was associated with 2019 novel coronavirus. This article reports a patient who presented with 2019 novel coronaviral pulmonary infection. The study protocol was approved by the Ethics Committees of the General Hospital of Ningxia Medical University, and the patient provided written informed consent.

Melanotic neuroectodermal tumour of infancy is an exceptional, benign, pigmented, melanin imbued neoplasm of neural crest origin, initially scripted by Krombecher in 1918. The rapidly progressive neoplasm denominates a locally aggressive, biphasic tumefaction composed of miniature, primitive, round, neuroblast-like, blue cells admixed with enlarged, melanin- producing, epitheloid cells.The neoplasm is diversely nomenclated as melanotic progonoma, melanotic hamartoma, melanoameloblastoma, melanotic adamantinoma, congenital melanocarcinoma, retinal anlage tumour or pigmented congenital epulis Incriminated infants can depict elevated levels of urinary vanillylmandelic acid (VMA), thus implying a neural crest origin.

Background: Hepatitis C virus (HCV) is an important cause of chronic hepatitis with necroinflammation and fibrosis resulting in end stage liver disease and hepatocellular carcinoma. Direct acting antivirals (DAAs) are newer agents that directly interfere with the HCV lifecycle and result in high rates of sustained virologic response (SVR). We evaluated if treatment with DAAs in a real-world setting is as successful in HCV/HIV coinfected patients as it is in HCV monoinfected patients, and if some degree of fibrosis regression can be observed after completion of therapy in both groups. Methods: We retrospectively reviewed data from HCV monoinfected and HCV/HIV coinfected patients who received treatment from 2014-2016 at the East Carolina University Infectious Diseases clinic. The primary outcome was to compare completion and sustained virologic response (SVR) rate at either 12 or 24 weeks between HCV monoinfected patients and HCV/HIV coinfected patients. The secondary outcome was to assess regression of fibrosis at either 12 or 24 weeks after completion of therapy, defined as one METAVIR stage improvement in their FibroSure™, a noninvasive biochemical test to estimate the stage of fibrosis. Results: There were 41 patients in each group. Compared to the coinfected group, patient no show rate was higher in the monoinfected group (p=0.0346). In the HCV monoinfected group, 25 (93%) achieved either SVR 12 or 24. Two patients were non-compliant and had detectable viral load on evaluation at week 12. In the HCV/HIV coinfected group, 37 patients achieved SVR (p=0.0039). One patient in the coinfected group did not complete therapy but achieved SVR. In terms of fibrosis, 12/18 (67%) in the monoinfected group demonstrated improvement in at least 1 Metavir stage and 6/18 (33%) had no change. In the coinfected group, 8/16 (50%) patients demonstrated an improvement in FibroSure™ stage, 5/16 (31%) had no change, and 3/16 (19%) had worsening fibrosis according to FibroSure™ stage, (p=0.4867). Conclusions: In this small, real-world cohort, HCV/HIV coinfected patients treated with DAAs had higher completion and SVR rates than HCV monoinfected patients. Treatment failures in the monoinfected group were all linked to non-adherence, whereas, more coinfected patients achieved SVR, likely related to the fact that they were regularly engaged in routine HIV care. Fibrosis regression based on FibroSure™ was observed more in monoinfected patients than those with coinfection. Although not statistically significant, at least 50% of the patients in each group had regression of fibrosis.