Pontine hemorrhage, a form of intracranial hemorrhage, is most commonly due to long standing poorly-controlled chronic hypertension. It carries a very poor prognosis. We report a 32 years-old pregnant mother who had a pontine hemorrhage in third trimester and was successfully managed with a multidisciplinary approach.

Craniofacial fibrous dysplasia [CF-FD] with orbital complications is a known but rare entity. This is a multi-modality imaging Case Report of extensive CF-FD in a 31-year-old male with right eye pain, swelling, and redness, along with histopathology correlation. In this patient, the CT scan demonstrates the classic ground glass bony appearance in great detail and helps with the diagnosis of FD, while excluding other bony pathology. The patient’s corroborative MRI brain with and without contrast and MRI brain perfusion images are presented to further characterize this pathology along with its orbital and ocular complications. Given the significant mass-effect on the ocular structures, the patient underwent orbital surgery with removal of as much of the lesion as possible. On macroscopic pathology evaluation, the affected bone was rubbery and gritty when sectioned. Microscopically, remnant fragments of woven bone of various size and shapes were seen with lack of an osteoblast rim. The bony fragments had a characteristic curvilinear, trabecular, and/or branching pattern. Post-surgical imaging demonstrated improvement in the mass-effect on orbital structures and proptosis, along with residual bony lesion.

Chronic granulomatous disease (CGD) is an unusual hereditary chief immune- deficiency disease, which is characterized by nicotinamide adenine dinucleotide phosphate oxidase (NADPH) system malfunction. In this type of disease the phagocytic cells could not be able to destroy the pathogens at the time of development of an infection. This will result in patients susceptibility to recurrent and intractable microbial infections. The disease is considered to be a genetically heterogeneous having equal susceptibility among all the ethnic groups. Patients with (CGD) suffer from persistent, fatal fungal and bacterial infections of the skin, the lymph nodes, airways, brain, liver, and bones. Whenever there is an infection with any odd microorganisms the susceptibility for CGD rises. In our article we aim to report a case study of a 4 months old female with disseminated candidiasis Tuberculosis lymphadenitis in details. The infant was treated successfully with antifungal voriconazole and broad spectrum antibacterial agents as well as anti-mycobacterial medications. When the patient was followed up later, it showed regression of the abnormal reports. But later developed CNS Candida and disseminated tuberculous with sequalae. Diagnosis was confirmed as heterozygous CYBA for p22phox, defect by genetic analysis. P22phox is an omnipresent protein which is coded by the gene CYBA located on the long arm of chromosome16. P22phox it is crucial factor of the enzyme superoxide-generating (NADPH) oxidase. Infection with bacteria, Candida lusitaniae is maximum among the patients who are suffering with haematological malignancies. The chance of the infection rises when the patient is receiving chemotherapy. This type of infection usually occurs among the patients who are presenting fungal infection that has already spread throughout the blood and among them only 7.3% of the patients are showing the symptomatic manifestations of peritonitis. However, the most difficult point is that the laboratory culture is not the answer for the growth of the particular microorganisms as these organisms are extremely difficult to culture or separate.

During odontogenesis, enamel is normally synthesized as an extracellular matrix, a phenomenon known as amelogenesis. The failure of this process can lead to malformation of dental enamel, called Amelogenesis Imperfecta (AI). AI, by causing a qualitative and/or quantitative deficiency of dental enamel, presents characteristics such as hypersensitivity, unsatisfactory aesthetics, reduced vertical dimension, anterior open bite, plaque accumulation, and greater susceptibility to caries and gingivitis. Thus, our objective is to report a case of AI, describing the main characteristics of the disease, the diagnosis and the rehabilitative treatment plan, aiming to improve the patients aesthetics and reestablishing the function of the stomatognathic system. Patient M.A.S.B., female, 5 years old, leucoderma, was admitted at the University of Patos de Minas Dental Clinic with a complaint of pain in the teeth. During the clinical interview, the person in charge reported that the childs teeth had the same defects as those of her mother and brother. During clinical examination it was observed: generalized loss of tooth structure, color change, rough surfaces and hypersensitivity. Treatment involved restorations with glass ionomer cement and composite resin, extraction of residual roots from the maxillary incisors, and confection of a functional and aesthetic space maintainer. Early diagnosis associated with the correct treatment plan is essential for a more conservative approach focused on preventing the effects of AI. In advanced cases, restoring function and aesthetics is paramount to improve the patients quality of life.

Background: The tibia, or shinbone, is the common fracture long bone in body. There are two option includes, reamed and unreamed of surgical treatment of fractures. Reamed nail has some advantage but they significantly harmful the endosteal circulation. Unreamed nail surplus the endosteal circulation but provide a less stable fixation. Afterward, because of ability to lock the nail proximally and distally, closed intramedullary nailing turned into an acknowledged treatment for closed shaft cracks during the ninth decade. Aim: The main objective is to treat the tibia fractures by implanting the Intramedullary nailing system (Interlocking cannulated tibia nail and Expert tibia nail) manufactured by Auxein Medical Private Limited, Sonipat, India. Material and Methods: In this retrospective study, studied the results of intramedullary tibia nail in treatment of tibia fracture. A total of 25 consecutive patients were included in this study (11male, 14 female and average age 42.9 years). Fracture type was classified as per the Muller AO classification of fracture. Results: The outcomes of clinical treatment were obtained in our study; No pain (92%), Mild pain (8%) after 2 year follow up. The follow up of patients were taken on 4-week, 1-year, 2-year according to VAS score. Paired t test was performed for statistical data analysis using Minitab and values of p<.05 were taken to indicate significant value with confidence interval of 95%. No implant related problem have been found like loosening, bending, corrosion etc. Conclusion: Our outcomes with interlocking cannulated and Expert tibial interlocking nailing are empowering and exhibit the advantages of new nailing framework. It has been concluded that intramedullary tibia nailing system is best method for treatment of tibia fracture with good results and outcomes.