Abstract :Menopause is defined as the time of the last menstrual period which is followed by 12 months of amenorrhea. Menopause is a time in which hormonal fluctuations occur in the females` body. Estrogen is responsible for many mechanisms inside the body. The symptomatic changes begin since the perimenopause transition till the permanent cessation of menstrual cycle. Ovaries are the only source of estrogen and progesterone.