Abstract :Human immunodeficiency virus(HIV)required the presence of CD4 receptor and chemokine receptor (CCR5?32)to inter into the CD4 host cell. Antiretroviral drugs only blocks the entry of HIV virus into the host cell. The cure of an HIV/AIDS patient the stem cell transplantation from an allogeneic and autologous donor who are homozygous for CCR5?32receptor mutation has increase research strategies to cure HIV/AIDS to induce long term remission without antiretroviral drugs. Natural CCR5?32 deficient donors and autologous stem cell transplantation of genetically modified hematopoietic stem cellsare currently under research.This review highlight the previous studies of stem cell transplantationin the treatment of HIV/AIDS.