Atrioventricular canal defect results from an abnormal or inadequate fusion of the superior and inferior endocardial cushions. Both the complete and partial types of the defect are associated with the ostium primum defect in the lowermost portion of the atrial septum, left ventricular outflow narrowing and the atrioventricular valve abnormalities. The clinical diagnosis of partial atrioventricular canal defect can be confirmed by cardiac ultrasound. The aim of this paper is to preset an educational ultrasound image of partial atrioventricular canal defect.

Our planet is a living creature that has its own protective viral mechanism. Viruses are activated when people too zealously intervene in the natural processes on the planet and worsen the environment. With a decrease in the spiritual level of society, a deterioration in ecology, climate change, a decrease in the frequency of the Schumann resonator supporting the energy healthy state of the body, pollution of water and soil and other catastrophic disorders of natural processes on the planet, an epidemic and the process of mutation of viruses begins, as a result of which more and more of their species appear. For the people will rise against the people and the kingdom against the kingdom; and there will be earthquakes in places, and there will be smoothness and turmoil. This is the beginning of Marks disease (13:8). The article discusses natural mechanisms and methods of protection against coronavirus.

Colorectal cancer (CRC), which is also referred to colorectal adenocarcinoma, occurs when the growth of cells goes out of control in the colon or rectum. A number of histological colorectal carcinoma are listed, such as mucinous, signet ring cell, and moderately differentiated adenocarcinoma. The present study included fifty tissue blocks (16 females and 34 males) of patient groups with CRC and thirty five tissue blocks of colon tissue (ulcerative colitis) which were used as control group. The mean age of patients group was 51.44±16.67 years. The majority of patients with colonic carcinoma were above the age of 40, accounting for 80%, while 20% of cases were below the age of 40 years. A recto-sigmoid location is the most common site for colonic tumors accounting for 60%. Grade of tumor was well differentiated in 56%, and the following features were observed: The tissue appears with multi-layering, back to back arrangement (little intervening stroma), loss of polarity, loss of goblet cells, and invasion of stroma and presence of nuclear criteria of malignancy: hyperchromatism, high N/C ratio visible nucleoli and abnormal mitosis. The present results also showed that in grade I lesion, most of tumor retains glandular pattern, moderately differentiated in 28%, and tumor is nearly equally composed of glandular and solid patterns. However the poorly differentiated was 16% with same cellular criteria of malignancy but almost all the tumor was composed of solid areas. The present findings divided the stage of tumor patients into: 22% stage I; 66% stage II, and 12% stage III.

Cirrhosis of liver is an end stage of chronic liver insults from varied etiologies which leads to impaired liver functions. Proteins expressed from liver and enters into circulation reflects degree of liver dysfunction. Serpins (Serine protease inhibitors) are class of plasma proteins expressed from liver; SERPINA4/Kallistatin is a multifunctional serpin clade A protein expressed from liver and concentration in serum is the reflection of extent of liver dysfunction. The present study aimed to compare cross reactivity of serpins for polyclonal and monospecific antibodies in both cirrhotic liver and healthy subjects. Blood samples were collected from 20 subjects (10 cirrhotic liver, 10 healthy) from R. L. Jalappa Hospital and Research Centre, Kolar, Karnataka, India. Separation of proteins was carried out by SDS-PAGE. Cross reactivity study was analyzed using western blot. Proteins present in cirrhotic liver and healthy subject’s serum were separated by SDS PAGE. There was no band detection on both (cirrhotic liver and healthy) PVDF (polyvinylidene diflouride) membranes with polyclonal antibodies. However, a significant band was observed with protein of interest in healthy PVDF membrane with monospecific antibodies. There was no band in cirrhotic liver PVDF membrane even with monospecific antibodies. Comparative cross reactivity analysis of serpins in quantification of SERPINA4/Kallistatin in the present study demonstrated that there will not be any immunological cross reactivity between serpins and SERPINA4/Kallistatin due to the absence of identical epitope in cirrhotic liver and healthy subjects.

What is acne vulgaris? A commonly diagnosed skin disease concerning clogging and inflammation of pilosebaceous units is called acne vulgaris. Mostly, adolescence and puberty are affected because of hormone and their daily routine. Gender is one of the critical factors to cause acne. Thus, excellent skin cares are needed to prevent acne vulgaris, leading to another symptom, including stress, low self-esteem, and depression. Importantly, due to our surroundings, there are many kinds of pollution that we have to face in our daily lives and cannot be avoided. One of the causes of acne is air pollution; air pollution can come in many kinds, such as UV rays, smoke, or PM (particulate matter). PM carries out small particles in the air that clog our skin pores or UV rays that directly damage our face if we do not have proper protection, resulting in acne outbreaks. Treating these acne outbreaks can be a lengthy and challenging process. Therefore, this review was to provide and update the method to shield and resolving the fair facial skin among air pollution surrounding. The author conducted this review thought collecting the article from Google Scholar and Pubmed using these keywords, including Acne vulgaris, air pollution, treatment, adolescence, self-esteem, and protection. There are a few steps that will protect and help resolve your skin from air pollution. First of all, cleansing your skin with a gentle cleanser is an excellent option to keep natural moisture in your skin. After cleansing, it is essential to use a gentle and soothing toner that helps remove grease and traces of dirt from blocking your pores, which might trigger acne. Scrubbing is the next step after the toner has been applied; mild scrubbing will ensure your skin is thoroughly cleansed of all harmful particles clogging your pores. Facial oil proves to boost moisten and shield your facial skin from toxic air substances. However, for long-term using facial oil can cause irritation to your skin, another option can be moisturizer instead. Make sure to apply sunscreen to protect against both UVB and UVA rays and apply it multiple times throughout the day when you are exposed to the air pollution. In addition, high sugary, salty and fats diets have the relationship with acne vulgaris. People with acne must avoid these types of food to reduce negative effect to acne. The protection and maintenance of facial skin is significantly important to make our face healthy. Moreover, the perks of having clear and healthy facial skin can boost up your confidence as well as decreasing our stress and anxiety that are being released throughout your body.