Introduction: Menopause is defined as the last menstruation cycle in women. Estrogen concentration in menopausal women was decreased and altered the lipid metabolism profiles. Menopausal women reportedly have a high risk of cardiovascular disease, arthritis, diabetes mellitus, and stroke. This study focused on the effect of the black-eyed pea diet on the lipid profiles in menopausal women. Methods: A randomized clinical study was performed to analyzedd the effect of the black-eyed pea diet on lipid profiles. Fifty-four menopausal women were selected as respondents and classified into two groups, black-eyed pea diet and placebo. Black-eyed pea diet treatment was performed by consuming black-eyed powder containing 67.5 mg of isoflavones and were monitored in week – 0 and week – 12 after treatment. Lipid profile of black-eyed pea diet and placebo in 12 weeks monitoring showed no significant value. After 12 weeks of treatment, total cholesterol and triglyceride were higher than before treatment. Results: Interestingly, the black-eyed pea diet increased the HDL and lowered the LDL after 12 weeks of treatment. Conclusion: This study concluded that black-eyed pea improved lipid profile, especially in elevating HDL level and decreasing LDL level in 12 weeks consumption.

Introduction: Menopause is defined as the last menstruation cycle in women. Estrogen concentration in menopausal women was decreased and altered the lipid metabolism profiles. Menopausal women reportedly have a high risk of cardiovascular disease, arthritis, diabetes mellitus, and stroke. This study focused on the effect of the black-eyed pea diet on the lipid profiles in menopausal women. Methods: A randomized clinical study was performed to analyzedd the effect of the black-eyed pea diet on lipid profiles. Fifty-four menopausal women were selected as respondents and classified into two groups, black-eyed pea diet and placebo. Black-eyed pea diet treatment was performed by consuming black-eyed powder containing 67.5 mg of isoflavones and were monitored in week – 0 and week – 12 after treatment. Lipid profile of black-eyed pea diet and placebo in 12 weeks monitoring showed no significant value. After 12 weeks of treatment, total cholesterol and triglyceride were higher than before treatment. Results: Interestingly, the black-eyed pea diet increased the HDL and lowered the LDL after 12 weeks of treatment. Conclusion: This study concluded that black-eyed pea improved lipid profile, especially in elevating HDL level and decreasing LDL level in 12 weeks consumption.

Introduction: Incidence of ectopic pregnancy can be an acute or chronic condition. The condition of chronic ectopic pregnancy itself is unique, arises from a minor rupture, and then develops into a hematocele. Chronic ectopic pregnancy is quite complicated to diagnose because it usually has a prolonged clinical course and can disappear spontaneously. Case Presentation: A woman aged 31-32 weeks, aged 24 years, complained of right abdominal pain accompanied by nausea and vomiting. Examination of vital signs was 120/80 mmHg, pulse 84 x/min, RR 20x/min, temperature 36.70C, and SpO2 of 98% with pale conjunctiva and abdominal tenderness in the right upper quadrant. On laboratory examination, the patient found severe microcytic normochromic anemia (Hb 4.5 mg/dl; MCV 96.6 Fl; MCH 30.2 pg), thrombocytopenia (platelets 133,000 L) and hypoalbumin (albumin 2.82 L). Ultrasound examination showed a mass in the right adnexa accompanied by intrauterine pregnancy. The patient underwent a laparotomy and found a mass in the form of a blood clot (hematocele) of 30x20x20 cm. Conclusion: Chronic ectopic pregnancy is a rare condition, especially in developed countries. A clinician should be more detailed in diagnosing and considering the ultrasound, an amorphous mass with avascularity to amass with complex vascular formation. This is very necessary considering that this hematocele mass can develop progressively to cause fetal growth disorders.

Introduction: Incidence of ectopic pregnancy can be an acute or chronic condition. The condition of chronic ectopic pregnancy itself is unique, arises from a minor rupture, and then develops into a hematocele. Chronic ectopic pregnancy is quite complicated to diagnose because it usually has a prolonged clinical course and can disappear spontaneously. Case Presentation: A woman aged 31-32 weeks, aged 24 years, complained of right abdominal pain accompanied by nausea and vomiting. Examination of vital signs was 120/80 mmHg, pulse 84 x/min, RR 20x/min, temperature 36.70C, and SpO2 of 98% with pale conjunctiva and abdominal tenderness in the right upper quadrant. On laboratory examination, the patient found severe microcytic normochromic anemia (Hb 4.5 mg/dl; MCV 96.6 Fl; MCH 30.2 pg), thrombocytopenia (platelets 133,000 L) and hypoalbumin (albumin 2.82 L). Ultrasound examination showed a mass in the right adnexa accompanied by intrauterine pregnancy. The patient underwent a laparotomy and found a mass in the form of a blood clot (hematocele) of 30x20x20 cm. Conclusion: Chronic ectopic pregnancy is a rare condition, especially in developed countries. A clinician should be more detailed in diagnosing and considering the ultrasound, an amorphous mass with avascularity to amass with complex vascular formation. This is very necessary considering that this hematocele mass can develop progressively to cause fetal growth disorders.

Introduction: Only a few published studies have directly demonstrated the effects of local soy isoflavone on the post-menopausal vaginal maturation index. This study focused on the effect of 24 weeks of local soy isoflavone (67.5 mg) consumption to improve the post-menopausal vaginal maturation index. Methods: 50 post-menopausal women were randomly assigned to a double-blind clinical trial to receive cowpea (Vigna unguiculata) powder treatment (n=25) and placebo (n=23). Vaginal cytology (maturation index, maturation value) was evaluated at pre and post-treatment in Anatomy Pathology Laboratories. Collected data were analyzed by using the analysis of covariant (ANOVA) method. Results: There is no difference in maturation vaginal index between the treatment and the placebo group. The treatment was not significantly improved the vaginal maturation index (p<0.05). The concomitant variable, age, post-menopausal interval, BMI, marital status, and initial cell condition have no significant effect on the maturation vagina index. Conclusion: Cowpea powder supplement with 67.5 mg isoflavone cannot improve the vaginal maturation index on post-menopausal patients.

Introduction: Doctors who died with COVID-19 were high and influenced by several factors. This study examined COVID-19 infected doctors and mortality risk factors in East Java. Methods: This observational cohort study was conducted among doctors infected with COVID-19 in East Java during March 2020-September 2021 and collected the COVID-19 infected doctors’ deaths report. Doctors received questionnaire on the status of COVID-19, history of infection, age, sex, type of doctor, type of specialization and resident, pregnancy, underlying disease and nutritional status. The doctors were followed up their COVID-19 condition. Data were described, and the association of potential risk factors was analyzed using univariate and multivariate analysis. Result: We reported 2041 doctors infected with COVID-19. Majority of them was male, 162 doctors were more than 59 years old, 162 doctors (7,9%) were died. The odds ratio in each risk factor for mortality was older age doctors 15,468 (95% CI 10,587-22,601), male 6,128 (95% CI 3,906-9,614), general practitioner 2,461 (95% CI 1,769-3,423), doctors with underlying disease 39,842 (95% CI 23,077-68,798), Type II diabetes mellitus 82,504 (95% CI 42,767-159,162), cardiovascular disease 50,152 (95% CI 16,672-150,866), hypertension 19,425 (95% CI 10,528-35,840), chronic obstructive pulmonary disease 5,52 (95% CI 0,610-49,992), obesity 30.750 (95% CI 15,293-61,828) and Pregnant doctors 43.013 (95% CI 10.986-168.414) (p<0,05). However, COPD and asthma showed not significant result in multivariate analysis. Conclusion: Older age, male, general practitioner, doctors with underlying disease, cardiovascular disease, Type II diabetes mellitus, hypertension, obesity, pregnant doctors had been mortality risk factors among COVID-19 infected doctors.

Introduction: Stunting has been a global burden worldwide, resulting in severe outcomes, including inadequate brain development until mortality. Early breastfeeding initiation as a global strategy affects the success of continuous breastfeeding that influences the children’s growth and development. This study aimed to provide a literature review on how early breastfeeding initiation might help children avoid stunting. Methods: We searched articles published from 2017 to 2022 in PubMed, Science Direct, Cochrane, and the Indonesia Database with keywords “Early breastfeeding initiation” OR “Early breastfeeding” OR” Early Initiation Breastfeeding” AND “stunting.” All data were gathered and analyzed. Results: A total of 12 articles from 6690 articles met the inclusion, exclusion, and eligibility criteria. The mean of early breastfeeding initiation was 61,82%, with the lowest study in Chimborazo and Tungurahua, Ecuador, and stunting was 33,07% as the highest prevalence was in Chimborazo and Tungurahua, Ecuador, while the lowest in Saharawi refugee camps, Algeria. The mean prevalence of children who did not get early breastfeeding initiation and stunting occurred at 40,85%, and eight studies reported that early breastfeeding initiation was associated with stunting. Conclusion: Early breastfeeding initiation can lower stunting risk in children. Early breastfeeding initiation ensures children obtain enough colostrum that enhances the children’s immunity and probability of exclusive breastfeeding, ensuring children obtain adequate nutritional intake and prevent stunting.