Background: Gingival recession can lead to root hypersensitivity, root caries, and impaired aesthetic concerns. Modified coronally advanced tunnel (MCAT) technique, which possesses various benefits that can be used to support the success in the treatment of gingival recession. Acellular dermal matrix (ADM) is used in the procedure, frequently documented indicating encouraging results in the treatment of gingival recession. The following case report is to indicate an evaluation on the treatment utilizing MCAT with ADM. Case presentation: A male of 27 year-old arrived with main complaints of aesthetic concerns and dental hypersensitivity on the upper right teeth posterior caused by Miller’s class I gingival recession. The aforementioned technique is chosen in treatment considering the rate of success to treat the defects as the impact of gingival recession. Case management: The MCAT with ADM commenced with the fabrication of composite stops at the contact points. Later local anaesthesia (lidocaine HCl 2% with epinephrine 1:100,000) was given. Intrasulcular incision was then made and the mucoperiosteal flap was raised with tunneling knives. The tunnel was then extended over the mucogingival junction. ADM was pulled into the tunnel by means of mattress sutures. Finally the tunnel was positioned coronally to the CEJ by means of suspended sutures placed around the contact points. Conclusion: The use of MCAT technique with ADM (Mucoderm) is able to show satisfying outcome with the improvement of root coverage in the case of Miller’s class I gingival recession.

Hypertension represents one of the most prevalent complications encountered during pregnancy, significantly contributing to both maternal and perinatal morbidity and mortality. The placenta, acting as a crucial feto-maternal organ, plays a pivotal role in sustaining pregnancy and fostering the healthy development of the fetus. Notably, the weight of the placenta holds functional importance, as it correlates with the villous surface area and fetal metabolism. Motivated by this context, the present study endeavors to examine the morphological and histological alterations in the placenta associated with hypertensive disorders of pregnancy and to assess their correlation with maternal and fetal outcomes. Methods: A prospective investigation encompassing 120 cases was conducted, comprising 60 normotensive mothers (Group A) and 60 mothers with hypertensive disorders of pregnancy (Group B). Placental specimens obtained from these participants were subjected to morphological and histological analyses, with subsequent correlation with maternal and fetal outcomes. Results: Our findings revealed a notable reduction in placental weight and dimensions within Group B compared to Group A. Histopathological examination unveiled a significant increase in the incidence of syncytial knots, fibrinoid necrosis, hyalinization, and calcification in placentas from the hypertensive group, directly correlating with neonatal complications. Furthermore, the mean neonatal birth weight was significantly higher in Group A compared to Group B. Conclusion: Hypertensive disorders of pregnancy exert a substantial impact on placental morphology, leading to diminished weight and dimensions, indicative of placental insufficiency attributable to compromised utero-placental blood flow. These alterations ultimately influence neonatal weight and overall neonatal outcomes. Our study underscores the presence of distinct morphological changes in the placenta that detrimentally affect fetal growth.

IL-17 is a member of the innate immune system, it is preferentially expressed by Th2 cells, and is highly recognized in psoriasis skin lesions. The current study aims investigate the role of Interleukin-17 (IL-17) in development and severity of psoriasis (PsO). Eighty persons from both genders are included in the study, 40 of them were patients and the same number were as control. Blood samples were taken from both groups and ELISA ready kit was used to estimate the sera levels of IL-17. The current findings pointed to a significant increase (p<0.05) in the of serum IL-17 in the patients’ group in comparison with the control group (20.97 ± 12.93 vs 20.97 ± 12.93 respectively). The results also showed that there is a highly significant increase in mean levels of IL-17 (20.3 pg/ml) in patients with moderate PsO and (20.8 pg/ml) for patients with severe PsO, compared to those with mild PSO. Conclusion: It was concluded that the high levels of IL-17 in psoriasis, and it seem that this interleukin may contribute to the severity of the disease. No gender differences were seen regarding the level of IL-17.

Objective: To analyze by means of a 3D finite element model the effect of anchoring dental implants in one or two cortical. Materials and Methods: An in vitro experimental investigation was performed using Finite Elements Analysis. Six conical implants of three different designs and different lengths were designed and placed in a 3D model of the anterior maxilla with type III bone, anchoring a first group of implants only in the occlusal cortical of the bone, while in a second group the apex of the implants was anchored in the cortex of the nasal passages too, so they become monocortical or bicortical anchored. Micromovements of the implants in the bone were generated by simulating a 60-degree inclined force applied at the abutment level with 170 Ncm and 700 Ncm. Amount of micromovements were measured. Results: Micromovements obtained when the implants were monocortical anchorage and subjected to forces of 170 Ncm, were similar for all the implants (average 27.4um). Whereas with forces of 700 Ncm, the micro-movements increased in all cases. (average 113.49 µm.) Micromovements decreased in all implants when bicortical anchorage was used, both when applying 170Ncm forces (average 8.58 µm) or applying 700Ncm forces (average 34.71µm). In relation to length, short implants showed less micromotion. Conclusion: According to the results obtained, bicortical anchoring reduces the micromotion of conical implants especially when they are subjected to parafunctional forces and in implants of greater length, ensuring levels of micromotion more compatible with osseointegration, at least in a three-dimensional simulation through FEA.

Responsible for the sensory stimuli of the viscerocranium, the 5th pair of cranial nerves, called the trigeminal nerve due to its 3 branches, is a mixed-function nerve. The diagnosis of Trigeminal Neuralgia is directly related to the symptoms reported by the patient during the anamnesis. The right treatment depends on the correct diagnosis. The exact etiology of TN is still unknown. It affects around 4 to 13 individuals per 100,000 and although it seems to be a neuropathy with a low incidence, it is the most common among facial pain syndromes. A retrospective cross-sectional observational study was carried out. We used data on laser therapy treatment for Trigeminal Neuralgia, received and treated at the Laser Clinic of the Faculty of Dentistry of the Federal University of Bahia, from 2003 to 2022. A total of 119 patients with a diagnosis of Trigeminal Neuralgia were treated, most of them with unilateral pain (89%). After diagnosis, the initial irradiation protocol was determined individually. The laser frequency applied was 808 nm (infrared) due to its greater ability to penetrate and activate chromophores in nerve and bone structures. The amount of energy applied varies from case to case, usually starting with 2 or 3 J per point, which is indicated for cases of regeneration and analgesia. The final status of the treatment is based on the patient’s score according to the visual analog scale, where 10 is the highest pain threshold and 0 is no pain. 65% of the patients related no pain or ate at least under 3 grades before the first degree Laser phototherapy is an effective means of recovery, reducing pain symptoms and improving the quality of life of patients with Trigeminal Neuralgia, and the infrared wave spectrum is the most suitable for this treatment.

Objective: Tonsillectomy is the most common surgery in the field of ENT. Pain is the most common post tonsillectomy complaint. Considering the importance of nursing cares in relieving post-surgery pain in general and post-tonsillectomy pain in particular, this study is conducted To assess Nurses knowledge towards nursing care of tonsillectomy in children and To find out the relationship between the Nurses knowledge and their selected demographic variables of age ,gender, level of education, years of experience, and training session. Methods: A Non-probability purposive sample of ( 120) nurses who are working in the operation rooms, surgical units and Ear, nose and throat units in these hospitals .The study was carried out from January 1st, 2023 up to April 28th, 2023. Conclusion: there are high significant relationship between the nurses’ age, hospital and their knowledge related to nursing care of children with tonsillectomy and there is a non-significant relationship with the remaining demographic and clinical data.

Purpose and Background: Post-traumatic stress disorder (PTSD) is a set of symptoms that appear after a severe traumatic stress. Children and adolescents experience an increase in potentially traumatic experiences. Many children subsequently develop mental health problems. Method: A broad search was conducted in scientific databases and search engines such as Science Direct, PubMed, Cochrane, Medline, SID, Scopus, CINAHL, OVID, Iran Doc, and Magiran with Using the keywords “post-traumatic stress disorder”, “non-pharmacological coping strategies”, “children” alone or in combination with each other and their English equivalent was done. Articles that were published between 2000 and 2023 and were more related to the main focus of the research topic were selected.After a comprehensive review, nine studies that met the purpose of this study were selected. Findings: The most important non-pharmacological treatment strategies in children included relaxation and hypnosis, acupuncture, neurofeedback, saikokeishikankyoto (a herbal preparation) and exercise (yoga). Conclusion: Therefore, the use of non-pharmacological methods as one of the effective methods in the treatment of these children’s disorders can improve the quality of life of the family of these patients and the patient himself, as a result, administrators should encourage the patients’ families by using non-pharmacological methods.

Background: Drug induced gingival enlargement is frequently observed in patients taking three main group of drugs like calcium channel blockers (CCBs), immunosuppressant’s and anticonvulsants. Amlodipine belongs to the dihydropyridine-a third generation calcium channel blockers agents that may cause the side effect of drug-induced gingival enlargement and oral bacteria intervention due to calculus retention. This case report describes the management of gingival enlargement in a hypertensive patient taking amlodipine. Purpose: This case report was aimed to discuss the treatment and maintenance of systemic observationsurgical periodontic approach to restore gingival enlargement. Case Report: A 47-years old man was referred to the Department of Periodontology, Faculty of Dentistry, Airlangga University complaining of swellings and bleeding on his gingiva in all region. He felt very uncomfortable as the swelling interfered while chewing and sometimes there was bleeding spontaneously and halitosis. He had hypertension since 5 years and was on medications Captopril 12,5 mg daily during 4 years and Amlodipine 5mg daily during last 1 year. A provisional diagnosis and systemic observation-periodontal phases treatment were taken to restore gingival enlargement condition. Case Management: Systemic observation of medication use, periodontal phases treatment such as scaling root planning, periodontal surgery as flap surgery, home oral hygiene maintenance, control recall every month during first 3 months were taken. Conclusion: The successful of combination carefully systemic observation-surgery periodontal approach are promising to maintain Amlodipine induced gingival enlargement.

Background: Gingival recession is apical migration of marginal gingiva, causing exposure of the root surface of the tooth.To treat this condition, free gingival autograft is used to increase the keratinized gingiva in the deformed area. The aim of the case is to prove the efficacy of Free Gingival Autograft technique in increasing amount of keratinized gingiva in area affected by gingival recession. Case presentation: In this clinical case presentation, a systemically healthy 61-years-old female come to the Periodontics Department of Airlangga Dental and Mouth Hospital seeking treatment for her mandibular front teeth which appeared to be elongated clinically and aesthetically unpleasing. Case management: The patient was treated by free gingival autograft. Graft is harvested from the palatal, placed, and sutured on the recipient site. 1 month post treatment follow up showed good result, evident with increased amount of keratinized mucosa in the previously deformed area. Conclusion: Gingival recession is a complex condition which can be treated with free gingival autograft. This technique showed satisfactory result, evident with increase of keratinized gingiva at 1 month follow-up.

The prognosis for pancreatic cancer (PC) is poor making it a substantial treatment challenge. A potentially effective treatment option is immunotherapy. To better understand the changing field of immunotherapy in PC management, this analysis will focus on important tactics and their consequences. To find relevant research published between 2019 and 2024, a thorough literature search was carried out using Scopus, Google Scholar, and PubMed. Tumor cells may be targeted and immune responses can be modulated using passive immunotherapeutic techniques such as CAR T-cell therapy and programmed death checkpoint inhibitors. Preclinical and clinical studies show enhanced effectiveness of combination therapy, such as anti-PD-1/anti-PD-L1 plus CTLA-4 inhibitors. Although their efficacy varies, active immunotherapeutic strategies, in particular cancer vaccines, seek to promote immune recognition of tumor antigens. Subpar response rates and treatment-related toxicity are obstacles. Checkpoint inhibitors, CAR T-cell therapy, and cancer vaccines are a few possible therapeutic options in the exciting field of immunotherapy for PC treatment. Nevertheless, further study is required to enhance these strategies and enhance patient.